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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1.1Jwan
targeted mutation 1.1, Jing H Wang
MGI:5449732
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6tm1.1Jwan/Bcl6tm1.1Jwan involves: 129S6/SvEvTac MGI:5449734
cx2
 		Aicdatm1Hon/Aicdatm1Hon
Bcl6tm1.1Jwan/Bcl6tm1.1Jwan 		involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj MGI:5449735


Genotype
MGI:5449734
hm1
Allelic
Composition		 Bcl6tm1.1Jwan/Bcl6tm1.1Jwan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Jwan mutation (0 available); any Bcl6 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:190534 )
N
• mice exhibit normal lymphocyte development, class switch recombination in vitro and immune response
abnormal somatic hypermutation frequency ( J:190534 )
• increased at the knock-in allele compared with wild-type mice

hematopoietic system
abnormal somatic hypermutation frequency ( J:190534 )
• increased at the knock-in allele compared with wild-type mice




Genotype
MGI:5449735
cx2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Bcl6tm1.1Jwan/Bcl6tm1.1Jwan
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Bcl6tm1.1Jwan mutation (0 available); any Bcl6 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal somatic hypermutation frequency ( J:190534 )
• mice fail to exhibit mutations in the knock-in allele

immune system
abnormal somatic hypermutation frequency ( J:190534 )
• mice fail to exhibit mutations in the knock-in allele




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory