Analysis Tools
muscle
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• normal muscle tissue weights or histology up to a year after tamoxifen treatment
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• in tamoxifen-treated mice subjected to a single cardiotoxin injury
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• satellite cells from tamoxifen-treated mice exhibit reduced ability to differentiate of satellite cell descendants ex vivo and increased self-renewal capacity in vivo compared with control cells
• ex vivo satellite cells from tamoxifen-treated mice exhibit increased self-renewal compared with control cells
• however, satellite cells exhibit normal quiescence, activation and proliferation and polarity of division
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• satellite cells from tamoxifen-treated mice form smaller myotubes containing fewer nuclei ex vivo compared with control cells
• regenerating muscle from tamoxifen-treated mice subjected to a single cardiotoxin injury exhibit smaller newly formed myofibers with fewer nuclei, numerous lagged fibers of small caliber, reduced cell size and necrotic myofibers compared with controls
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