Phenotypes associated with this allele

• Allele Symbol: Tg(SOD1*A4V)A1073Gur
• Allele Name: transgene insertion A1073, Mark E Gurney
• Allele ID: MGI:5449884
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(SOD1)2Gur/0 Tg(SOD1*A4V)A1073Gur/0	involves: C57BL/6 * SJL	MGI:5449900
tg2	Tg(SOD1*A4V)A1073Gur/0	involves: C57BL/6 * SJL	MGI:5449885

Genotype
MGI:5449900

cx1

• Allelic Composition: Tg(SOD1)2Gur/0; Tg(SOD1*A4V)A1073Gur/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:109458 )

• lifespan is on average 318.5 days

nervous system

abnormal spinal cord grey matter morphology ( J:109458 )

• mutants exhibit protein aggregates in spinal cords

abnormal nervous system physiology ( J:109458 )

• mutants develop an amyotrophic lateral sclerosis-like phenotype, with an average onset of disease at 227.4 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:109458

Genotype
MGI:5449885

tg2

• Allelic Composition: Tg(SOD1*A4V)A1073Gur/0
• Genetic Background: involves: C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:32665 , J:109458 )

• mice appear normal and do not develop motor neuron disease (J:32665)