Phenotypes associated with this allele

• Allele Symbol: Nlrp1b^tm1Bhk
• Allele Name: targeted mutation 1, Beverly H Koller
• Allele ID: MGI:5449888
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp1b^tm1Bhk/Nlrp1b^tm1Bhk	129S6/SvEvTac-Nlrp1b^tm1Bhk	MGI:5450819

Genotype
MGI:5450819

hm1

• Allelic Composition: Nlrp1b^tm1Bhk/Nlrp1b^tm1Bhk
• Genetic Background: 129S6/SvEvTac-Nlrp1b^tm1Bhk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:189777 )

• macrophages are protected from very lose dose anthrax lethal toxin-induced cell death and pyroptosis

• macrophages exposed to anthrax lethal toxin exhibit reduced levels of lactate dehydrogenase, IL1a and IL1b compared with control cells

• however, increasing anthrax LT induces cell death normally and muramyl dipeptide and peptidoglycan-mediated release of IL1b is normal

decreased interleukin-1 alpha secretion ( J:189777 )

• in macrophages exposed to anthrax lethal toxin

decreased interleukin-1 beta secretion ( J:189777 )

• in macrophages exposed to anthrax lethal toxin

• however, muramyl dipeptide or peptidoglycan-mediated release of IL1b is normal

homeostasis/metabolism

decreased lactate dehydrogenase level ( J:189777 )

• in macrophages exposed to anthrax lethal toxin

decreased susceptibility to injury ( J:189777 )

• mice are protected from anthrax lethal toxin-mediated acute lung injury without an increase in IL1b levels, total cell numbers and lactate dehydrogenase levels in the bronchoalveolar lavage fluid compared with wild-type mice

hematopoietic system

abnormal macrophage physiology ( J:189777 )

• macrophages are protected from very lose dose anthrax lethal toxin-induced cell death and pyroptosis

• macrophages exposed to anthrax lethal toxin exhibit reduced levels of lactate dehydrogenase, IL1a and IL1b compared with control cells

• however, increasing anthrax LT induces cell death normally and muramyl dipeptide and peptidoglycan-mediated release of IL1b is normal