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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(9Casp1-Casp4)1Bhk
deletion, Chr 9, Beverly H Koller 1
MGI:5449892
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Del(9Casp1-Casp4)1Bhk/Del(9Casp1-Casp4)1Bhk 129-Del(9Casp1-Casp4)1Bhk MGI:5450820


Genotype
MGI:5450820
hm1
Allelic
Composition
Del(9Casp1-Casp4)1Bhk/Del(9Casp1-Casp4)1Bhk
Genetic
Background
129-Del(9Casp1-Casp4)1Bhk
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages are protected from very lose dose anthrax lethal toxin-induced pyroptosis
• in macrophages exposed to LPS and anthrax lethal toxin
• in macrophages exposed to LPS and anthrax lethal toxin
• in macrophages exposed to titanium oxide with or without muramyl dipeptide or peptidoglycan
• in macrophages exposed to L18-muramyl dipeptide

homeostasis/metabolism
• in macrophages exposed to anthrax lethal toxin
• mice are protected from anthrax toxin lethal toxin-induced lung inflammation with reduced inflammatory cell infiltrate, cell death, vascular permeability and chemokine levels compared with control mice

hematopoietic system
• macrophages are protected from very lose dose anthrax lethal toxin-induced pyroptosis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory