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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(CMV-GFP)Nat
targeted mutation 1, Jeremy Nathans
MGI:5449926
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+ 		involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J MGI:6487970
ot2
 		Hprt1tm1(CMV-GFP)Nat/Y involves: 129P2/OlaHsd * C57BL/6 MGI:5532745


Genotype
MGI:6487970
cx1
Allelic
Composition		 Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+
Genetic
Background		 involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
Hprt1tm1(CMV-GFP)Nat mutation (1 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased oligodendrocyte progenitor number ( J:291492 )
• increased proportion of cells containing KO allele among Ki67+ oligodendrocyte precursor cells (OPCs) at age P6
• increased proportion of cells containing KO allele among Olig2+ oligodendrocyte precursor cells (OPCs) in E14.5 embryos
increased oligodendrocyte number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ CC1+ differentiated oligodendrocytes at age P14
• increased expression of myelin basic protein in KO allele expressing oligodendrocytes at age P14
• normal proportion of cells containing KO allele among Olig2+ CC1+ differentiated oligodendrocytes and normal myelin basic protein expression at age P30

cellular
increased oligodendrocyte progenitor number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ oligodendrocyte precursor cells (OPCs) in E14.5 embryos
• increased proportion of cells containing KO allele among Ki67+ oligodendrocyte precursor cells (OPCs) at age P6




Genotype
MGI:5532745
ot2
Allelic
Composition		 Hprt1tm1(CMV-GFP)Nat/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CMV-GFP)Nat mutation (1 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:220411 )
• homozygous females and hemizygous males are viable and fertile




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory