All Phenotypes Il10ra<tm1.1Tlg> MGI Mouse

immune system phenotype ( J:189797 )

N	• no abnormal phenotype is observed in mice in which autoimmune encephalitis has not been induced

• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis

abnormal lymphocyte cell number ( J:189797 )

abnormal regulatory T cell number ( J:189797 )

• increased proportion of regulatory T cells early in the course of experimental autoimmune encephalitis

decreased T cell number ( J:189797 )

• decreased overall T cell accumulation during the course of experimental autoimmune encephalitis

autoimmune response ( J:189797 )

• autoimmune encephalitis induced by treatment with myelin oligodendrocyte glycoprotein peptide results in less severe disease than in controls

• time to initial symptoms similar to controls

• disease state is qualitatively similar to controls

• no mortality due to experimental autoimmune encephalitis

• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis

abnormal lymphocyte cell number ( J:189797 )

abnormal regulatory T cell number ( J:189797 )

• increased proportion of regulatory T cells early in the course of experimental autoimmune encephalitis

decreased T cell number ( J:189797 )

• decreased overall T cell accumulation during the course of experimental autoimmune encephalitis

• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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