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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il10ratm1.1Tlg
targeted mutation 1.1, Terrence L Geiger
MGI:5450726
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Il10ratm1.1Tlg/Il10ratm1.1Tlg
Tg(Cd4-cre)1Cwi/?
B6.Cg-Tg(Cd4-cre)1Cwi Il10ratm1.1Tlg MGI:5450805


Genotype
MGI:5450805
cn1
Allelic
Composition
Il10ratm1.1Tlg/Il10ratm1.1Tlg
Tg(Cd4-cre)1Cwi/?
Genetic
Background
B6.Cg-Tg(Cd4-cre)1Cwi Il10ratm1.1Tlg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ratm1.1Tlg mutation (1 available); any Il10ra mutation (32 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• no abnormal phenotype is observed in mice in which autoimmune encephalitis has not been induced
• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis
• increased proportion of regulatory T cells early in the course of experimental autoimmune encephalitis
• decreased overall T cell accumulation during the course of experimental autoimmune encephalitis
• autoimmune encephalitis induced by treatment with myelin oligodendrocyte glycoprotein peptide results in less severe disease than in controls
• time to initial symptoms similar to controls
• disease state is qualitatively similar to controls
• no mortality due to experimental autoimmune encephalitis

hematopoietic system
• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis
• increased proportion of regulatory T cells early in the course of experimental autoimmune encephalitis
• decreased overall T cell accumulation during the course of experimental autoimmune encephalitis

cellular
• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis





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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory