Phenotypes associated with this allele

• Allele Symbol: Fcmr^tm1Ohno
• Allele Name: targeted mutation 1, Hiroshi Ohno
• Allele ID: MGI:5450845
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcmr^tm1Ohno/Fcmr^tm1Ohno	B6.129-Fcmr^tm1Ohno	MGI:5450846

Genotype
MGI:5450846

hm1

• Allelic Composition: Fcmr^tm1Ohno/Fcmr^tm1Ohno
• Genetic Background: B6.129-Fcmr^tm1Ohno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell number ( J:190117 )

• increased about 2 fold in the peritoneal cavity

abnormal B cell morphology ( J:190117 )

• the CD21 and CD23 levels are slightly lower on splenic B cells compared to controls

decreased marginal zone B cell number ( J:190117 )

• 4 fold decrease in the number of CD23-/CD21hi or CD1d+/CD5lo marginal zone B cells

• however, the total number of splenic B cells is indistinguishable from controls

increased B-1 B cell number ( J:190117 )

• increased about 2 fold in the spleen but not in the peritoneal cavity

abnormal immunoglobulin level ( J:190117 )

decreased IgG1 level ( J:190117 )

• decreased primary IgG1 response to both nitrophenyl and chicken gamma-globulin

increased IgG3 level ( J:190117 )

• two-fold higher in naive mice compared to controls

• following inoculation with 10^4 cfu of Streptococcus pneumoniae (R36A) IgM and IgG3 phosphorylcholine specific antibodies are markedly elevated

decreased IgM level ( J:190117 )

• recall IgM responses are impaired in mice receiving the highest dose of nitrophenyl-coupled chicken gamma-globulin (NP23-CGG) in PBS

increased IgM level ( J:190117 )

• two-fold higher in naive mice compared to controls

• following inoculation with 10^4 cfu of Streptococcus pneumoniae (R36A) IgM and IgG3 phosphorylcholine specific antibodies are markedly elevated

increased anti-chromatin antibody level ( J:190117 )

• in naive mice at 10-15 weeks of age

increased anti-double stranded DNA antibody level ( J:190117 )

• in naive mice at 10-15 weeks of age

abnormal response to infection ( J:190117 )

• following inoculation with 10^4 cfu of Streptococcus pneumoniae (R36A) IgM and IgG3 phosphorylcholine specific antibodies are markedly elevated

hematopoietic system

increased T cell number ( J:190117 )

• increased about 2 fold in the peritoneal cavity

abnormal B cell morphology ( J:190117 )

• the CD21 and CD23 levels are slightly lower on splenic B cells compared to controls

decreased marginal zone B cell number ( J:190117 )

• 4 fold decrease in the number of CD23-/CD21hi or CD1d+/CD5lo marginal zone B cells

• however, the total number of splenic B cells is indistinguishable from controls

increased B-1 B cell number ( J:190117 )

• increased about 2 fold in the spleen but not in the peritoneal cavity

abnormal immunoglobulin level ( J:190117 )

decreased IgG1 level ( J:190117 )

• decreased primary IgG1 response to both nitrophenyl and chicken gamma-globulin

increased IgG3 level ( J:190117 )

• two-fold higher in naive mice compared to controls

• following inoculation with 10^4 cfu of Streptococcus pneumoniae (R36A) IgM and IgG3 phosphorylcholine specific antibodies are markedly elevated

decreased IgM level ( J:190117 )

• recall IgM responses are impaired in mice receiving the highest dose of nitrophenyl-coupled chicken gamma-globulin (NP23-CGG) in PBS

increased IgM level ( J:190117 )

• two-fold higher in naive mice compared to controls

• following inoculation with 10^4 cfu of Streptococcus pneumoniae (R36A) IgM and IgG3 phosphorylcholine specific antibodies are markedly elevated