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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dp(17Nfkbil1-Or2h1)1Cogr
duplication, Chr 17, Cornelius Gross 1
MGI:5451036
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dp(17Nfkbil1-Or2h1)1Cogr/Dp(17Nfkbil1-Or2h1)1Cogr involves: 129S6/SvEvTac * C57BL/6J MGI:5451043
cx2
 		Apoetm1Unc/Apoetm1Unc
Dp(17Nfkbil1-Or2h1)1Cogr/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5451045
cx3
 		ApcMin/Apc+
Dp(17Nfkbil1-Or2h1)1Cogr/0 		involves: 129S6/SvEvTac * C57BL/6J MGI:5451046
ot4
 		Dp(17Nfkbil1-Or2h1)1Cogr/0 involves: 129S6/SvEvTac * C57BL/6J MGI:5451044


Genotype
MGI:5451043
hm1
Allelic
Composition		 Dp(17Nfkbil1-Or2h1)1Cogr/Dp(17Nfkbil1-Or2h1)1Cogr
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available); any Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5451045
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Dp(17Nfkbil1-Or2h1)1Cogr/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (152 available)
Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available); any Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased susceptibility to atherosclerosis in Apoetm1Unc/Apoetm1Unc Dp(17Nfkbil1-Or2h1)1Cogr/0 mice

cardiovascular system
decreased susceptibility to atherosclerosis ( J:190754 )
• mice fed a high fat diet develop smaller plaques than in Apoetm1Unc homozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:190754 )
N
• mice fed a high fat diet exhibit the same cholesterol and glucose serum levels and glucose tolerance as Apoetm1Unc homozygotes




Genotype
MGI:5451046
cx3
Allelic
Composition		 ApcMin/Apc+
Dp(17Nfkbil1-Or2h1)1Cogr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (156 available)
Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available); any Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:190754 )
N
• mice exhibit the same tumor-free survival as ApcMin heterozygotes




Genotype
MGI:5451044
ot4
Allelic
Composition		 Dp(17Nfkbil1-Or2h1)1Cogr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available); any Dp(17Nfkbil1-Or2h1)1Cogr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:190754 )
N
• mice exhibit normal hematological and immunological parameters

immune system
immune system phenotype ( J:190754 )
N
• mice exhibit normal hematological and immunological parameters




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory