mortality/aging
• life span is 12 months compared with 24 months for wild-type mice
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immune system
• ex vivo T cells exhibit increased activated proinflammatory T cell phenotype compared with wild-type cells
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• CD4+ T cells stimulation with polyclonal anti-CD3/anti-CD28 exhibit increased frequency of IFN-gamma expressing cells compared with wild-type cells
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• in untreated mice and mice treated with MOG peptide
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• in untreated mice and mice treated with MOG peptide
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• from lymph node and spleen T cells ex vivo
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• from lymph node and spleen T cells ex vivo
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• MOG peptide-treated mice exhibit reduced experimental autoimmune encephalomyelitis severity with reduced CNS cellular infiltration compared with control mice
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hematopoietic system
• ex vivo T cells exhibit increased activated proinflammatory T cell phenotype compared with wild-type cells
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• CD4+ T cells stimulation with polyclonal anti-CD3/anti-CD28 exhibit increased frequency of IFN-gamma expressing cells compared with wild-type cells
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endocrine/exocrine glands