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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc33tm1.1Cwh
targeted mutation 1.1, Caroline C Whitacre
MGI:5451057
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc33tm1.1Cwh/Mirc33tm1.1Cwh involves: 129X1/SvJ MGI:5451078


Genotype
MGI:5451078
hm1
Allelic
Composition		 Mirc33tm1.1Cwh/Mirc33tm1.1Cwh
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:189763 )
• life span is 12 months compared with 24 months for wild-type mice

immune system
abnormal T cell morphology ( J:189763 )
• ex vivo T cells exhibit increased activated proinflammatory T cell phenotype compared with wild-type cells
increased T-helper 1 cell number ( J:189763 )
• CD4+ T cells stimulation with polyclonal anti-CD3/anti-CD28 exhibit increased frequency of IFN-gamma expressing cells compared with wild-type cells
lymph node hypoplasia ( J:189763 )
• in untreated mice and mice treated with MOG peptide
lymphoid hypoplasia ( J:189763 )
• in untreated mice and mice treated with MOG peptide
increased interferon-gamma secretion ( J:189763 )
• from lymph node and spleen T cells ex vivo
increased interleukin-17 secretion ( J:189763 )
• from lymph node and spleen T cells ex vivo
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:189763 )
• MOG peptide-treated mice exhibit reduced experimental autoimmune encephalomyelitis severity with reduced CNS cellular infiltration compared with control mice

hematopoietic system
abnormal T cell morphology ( J:189763 )
• ex vivo T cells exhibit increased activated proinflammatory T cell phenotype compared with wild-type cells
increased T-helper 1 cell number ( J:189763 )
• CD4+ T cells stimulation with polyclonal anti-CD3/anti-CD28 exhibit increased frequency of IFN-gamma expressing cells compared with wild-type cells

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory