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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Calcatm1.1(cre/ERT2)Ptch
targeted mutation 1.1, Pao-Tien Chuang
MGI:5460801
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Calcatm1.1(cre/ERT2)Ptch/Calca+
Trp53tm1Brn/Trp53tm1Brn
Rb1tm2Brn/Rb1tm2Brn
Ptentm1Hwu/Ptentm1Hwu 		involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N MGI:5460854
cn2
 		Calcatm1.1(cre/ERT2)Ptch/Calca+
Trp53tm1Brn/Trp53tm1Brn
Rb1tm2Brn/Rb1tm2Brn 		involves: 129 * 129P2/OlaHsd * FVB/N MGI:5460840
cn3
 		Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Calcatm1.1(cre/ERT2)Ptch/Calca+ 		involves: 129P2/OlaHsd * 129S/SvEv MGI:5460837


Genotype
MGI:5460854
cn1
Allelic
Composition		 Calcatm1.1(cre/ERT2)Ptch/Calca+
Trp53tm1Brn/Trp53tm1Brn
Rb1tm2Brn/Rb1tm2Brn
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcatm1.1(cre/ERT2)Ptch mutation (0 available); any Calca mutation (23 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:190366 )
• death within 3 months of tamoxifen treatment

respiratory system
increased lung small cell carcinoma incidence ( J:190366 )
• small cell lung tumors 2.5 months after tamoxifen treatment
abnormal pulmonary neuroendocrine body morphology ( J:190366 )
• increased proliferation of pulmonary neuroendocrine cells

neoplasm
increased thyroid tumor incidence ( J:190366 )
• all mice develop thyroid tumors
increased metastatic potential ( J:190366 )
• increased invasiveness at 2.5 months after tamoxifen treatment
increased lung small cell carcinoma incidence ( J:190366 )
• small cell lung tumors 2.5 months after tamoxifen treatment

endocrine/exocrine glands
increased thyroid tumor incidence ( J:190366 )
• all mice develop thyroid tumors




Genotype
MGI:5460840
cn2
Allelic
Composition		 Calcatm1.1(cre/ERT2)Ptch/Calca+
Trp53tm1Brn/Trp53tm1Brn
Rb1tm2Brn/Rb1tm2Brn
Genetic
Background		 involves: 129 * 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcatm1.1(cre/ERT2)Ptch mutation (0 available); any Calca mutation (23 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:190366 )
• death within 6-7 months of tamoxifen treatment

respiratory system
increased lung small cell carcinoma incidence ( J:190366 )
• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well
abnormal pulmonary neuroendocrine body morphology ( J:190366 )
• pulmonary neuroendocrine cells hyperplasia 5-6 months after tamoxifen treatment in 16 of 32 mice examined
• increased proliferation of pulmonary neuroendocrine cells

neoplasm
increased thyroid tumor incidence ( J:190366 )
• all mice develop thyroid tumors
increased lung small cell carcinoma incidence ( J:190366 )
• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

endocrine/exocrine glands
increased thyroid tumor incidence ( J:190366 )
• all mice develop thyroid tumors




Genotype
MGI:5460837
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Calcatm1.1(cre/ERT2)Ptch/Calca+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcatm1.1(cre/ERT2)Ptch mutation (0 available); any Calca mutation (23 available)
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal club cell morphology ( J:190366 )
• clara cell numbers recover after tamoxifen and/or naphthalene lung injury regardless of presence or absence of pulmonary neuroendocrine cells
abnormal pulmonary neuroendocrine body morphology ( J:190366 )
• pulmonary neuroendocrine cells ablated by tamoxifen treatment are not replaced at 1, 6, 10, and 12 months after treatment
• naphthalene lung injury fails to induce restoration of this cell type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory