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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgd4tm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5460855
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fgd4tm1Ics/Fgd4tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+ 		involves: 129S1/Sv MGI:5460883
cn2
 		Fgd4tm1Ics/Fgd4tm1Ics
Tg(Plp1-cre/ERT2)1Ueli/0 		involves: C57BL/6 * DBA/2 MGI:5460888
cn3
 		Fgd4tm1Ics/Fgd4tm1Ics
Tg(Dhh-cre)1Mejr/0 		involves: FVB/N MGI:5460880


Genotype
MGI:5460883
cn1
Allelic
Composition		 Fgd4tm1Ics/Fgd4tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgd4tm1Ics mutation (0 available); any Fgd4 mutation (83 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:190437 )
N
• normal myelination of plantaris, quadriceps or saphenous nerves




Genotype
MGI:5460888
cn2
Allelic
Composition		 Fgd4tm1Ics/Fgd4tm1Ics
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgd4tm1Ics mutation (0 available); any Fgd4 mutation (83 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelin sheath morphology ( J:190437 )
• mutants injected with tamoxifen exhibit aberrant myelin in peripheral nerves at 30 weeks of age




Genotype
MGI:5460880
cn3
Allelic
Composition		 Fgd4tm1Ics/Fgd4tm1Ics
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgd4tm1Ics mutation (0 available); any Fgd4 mutation (83 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:190437 )
• aberrant myelin formation and myelin in peripheral nerves




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory