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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock2m3Btlr
mutation 3, Bruce Beutler
MGI:5461202
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock2m3Btlr/Dock2m3Btlr C57BL/6J-Dock2m3Btlr MGI:5461205


Genotype
MGI:5461205
hm1
Allelic
Composition		 Dock2m3Btlr/Dock2m3Btlr
Genetic
Background		 C57BL/6J-Dock2m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m3Btlr mutation (1 available); any Dock2 mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:191187 )
• CD4+ T cells are depleted
abnormal immune system physiology ( J:191187 )
• mice lack a T-dependent IgG response
• however, T-independent IgM response is normal

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:191187 )
• CD4+ T cells are depleted




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory