Phenotypes associated with this allele

• Allele Symbol: Il7^tm2.1Iku
• Allele Name: targeted mutation 2.1, Koichi Ikuta
• Allele ID: MGI:5461219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il7^tm2.1Iku/Il7^tm2.1Iku Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA	MGI:5461227

Genotype
MGI:5461227

cn1

• Allelic Composition: Il7^tm2.1Iku/Il7^tm2.1Iku; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:190615 )

N • mice exhibit normal numbers of hepatic NK, dendritic and B cells

N • development and maintenance of NK T and T cells in the lymphoid organs is normal

abnormal B cell differentiation ( J:190615 )

• impaired fetal and neonatal B cell development

decreased lymphocyte cell number ( J:190615 )

• intrahepatic lymphocytes

decreased B cell number ( J:190615 )

• in fetal and neonatal liver samples

decreased T cell number ( J:190615 )

• in the liver

decreased double-negative T cell number ( J:190615 )

• in the liver

decreased NK T cell number ( J:190615 )

• of NK T and invariant NK T (5-fold) cells in the liver

• however, the number of invariant NK T cells in the thymus and spleen is normal

abnormal NK T cell physiology ( J:190615 )

• impaired hepatic invariant NK T cell maintenance

• however, development and maintenance of NK T and T cells in the lymphoid organs is normal

hematopoietic system

hematopoietic system phenotype ( J:190615 )

N • mice exhibit normal numbers of hematopoietic progenitors

abnormal B cell differentiation ( J:190615 )

• impaired fetal and neonatal B cell development

decreased lymphocyte cell number ( J:190615 )

• intrahepatic lymphocytes

decreased B cell number ( J:190615 )

• in fetal and neonatal liver samples

decreased T cell number ( J:190615 )

• in the liver

decreased double-negative T cell number ( J:190615 )

• in the liver

decreased NK T cell number ( J:190615 )

• of NK T and invariant NK T (5-fold) cells in the liver

• however, the number of invariant NK T cells in the thymus and spleen is normal

abnormal NK T cell physiology ( J:190615 )

• impaired hepatic invariant NK T cell maintenance

• however, development and maintenance of NK T and T cells in the lymphoid organs is normal