Phenotypes associated with this allele

• Allele Symbol: Men1^tm1Rvt
• Allele Name: targeted mutation 1, Rajesh V Thakker
• Allele ID: MGI:5461232
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Men1^tm1Rvt/Men1^tm1Rvt	involves: 129 * C57BL/6	MGI:5461307
ht2	Men1^tm1Rvt/Men1^+	involves: 129 * C57BL/6	MGI:5461308

Genotype
MGI:5461307

hm1

• Allelic Composition: Men1^tm1Rvt/Men1^tm1Rvt
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:191261 )

Genotype
MGI:5461308

ht2

• Allelic Composition: Men1^tm1Rvt/Men1⁺
• Genetic Background: involves: 129 * C57BL/6

nervous system

increased pituitary gland tumor incidence ( J:191261 )

increased pituitary adenohypophysis tumor incidence ( J:191261 )

mortality/aging

decreased tumor-free survival time ( J:191261 )

• associated with tumor development

reproductive system

increased ovary tumor incidence ( J:191261 )

• in mice older than 12 months

increased Leydig cell number ( J:191261 )

increased testis tumor incidence ( J:191261 )

neoplasm

increased tumor incidence ( J:191261 )

• due to loss of allelic heterozygosity

• in 5% of mice younger than 9 months

• in 84% of mice older than 12 months (parathyroid, pancreatic islet, anterior pituitary, adrenal cortex, thyroid, testis and ovary)

increased adrenal cortical tumor incidence ( J:191261 )

• in mice older than 12 months

increased pituitary gland tumor incidence ( J:191261 )

increased pituitary adenohypophysis tumor incidence ( J:191261 )

increased parathyroid gland tumor incidence ( J:191261 )

• in mice older than 12 months

increased parathyroid adenoma incidence ( J:191261 )

• solid or papillary adenomas

increased thyroid tumor incidence ( J:191261 )

• in mice older than 12 months

increased pancreatic islet cell adenoma incidence ( J:191261 )

• in mice older than 12 months

increased ovary tumor incidence ( J:191261 )

• in mice older than 12 months

increased testis tumor incidence ( J:191261 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:191261 )

N • mice exhibit normal parathyroid hormone and chromogranin A serum levels

increased circulating corticosterone level ( J:191261 )

♂ • in one male mouse with adrenal cortical tumors

increased circulating calcium level ( J:191261 )

• in mice with parathyroid proliferative abnormalities

• in mice with thyroid abnormalities

decreased circulating phosphate level ( J:191261 )

• in mice with parathyroid proliferative abnormalities

• however, mice with thyroid abnormalities exhibit normal phosphate serum levels

endocrine/exocrine glands

increased adrenal cortical tumor incidence ( J:191261 )

• in mice older than 12 months

pancreatic islet hyperplasia ( J:191261 )

increased pituitary gland tumor incidence ( J:191261 )

increased pituitary adenohypophysis tumor incidence ( J:191261 )

parathyroid gland hyperplasia ( J:191261 )

increased parathyroid gland tumor incidence ( J:191261 )

• in mice older than 12 months

increased parathyroid adenoma incidence ( J:191261 )

• solid or papillary adenomas

increased thyroid tumor incidence ( J:191261 )

• in mice older than 12 months

increased pancreatic islet cell adenoma incidence ( J:191261 )

• in mice older than 12 months

increased ovary tumor incidence ( J:191261 )

• in mice older than 12 months

increased Leydig cell number ( J:191261 )

increased testis tumor incidence ( J:191261 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple endocrine neoplasia type 1		DOID:10017	OMIM:131100	J:191261