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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1.1Mtto
targeted mutation 1.1, Toshitada Takemori
MGI:5461311
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl MGI:5461329
cn2
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 * C57BL/6JJcl MGI:5461328
cn3
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0 		involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2 MGI:5461331
cn4
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6JJcl * DBA/2 MGI:5461330


Genotype
MGI:5461329
cn1
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (57 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:190943 )
N
• mice immunized with NP-CG exhibit normal development of memory B cells
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells

hematopoietic system
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells




Genotype
MGI:5461328
cn2
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (57 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:190943 )
• memory B cells from mice immunized with NP-CG fail to undergo somatic hypermutation compared with wild-type mice
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 5 and 7 (200-fold)
abnormal memory B cell morphology ( J:190943 )
• early germinal center memory B cells from mice immunized with NP-CG exhibit a resting state compared with wild-type mice
• however, the number of memory B cells is normal
abnormal memory B cell physiology ( J:190943 )
• 40 days after immunization with NP-CG, GC-independent memory B cells arise from dividing precursors, fail to exhibit a decrease in proliferation unlike wild-type cells and enter the memory compartment before germinal B cell progeny
abnormal humoral immune response ( J:190943 )
• memory B cells from mice treated with NP-CG produce low affinity antibodies in an IgG1 secondary response unlike wild-type cells

hematopoietic system
abnormal somatic hypermutation frequency ( J:190943 )
• memory B cells from mice immunized with NP-CG fail to undergo somatic hypermutation compared with wild-type mice
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 5 and 7 (200-fold)
abnormal memory B cell morphology ( J:190943 )
• early germinal center memory B cells from mice immunized with NP-CG exhibit a resting state compared with wild-type mice
• however, the number of memory B cells is normal
abnormal memory B cell physiology ( J:190943 )
• 40 days after immunization with NP-CG, GC-independent memory B cells arise from dividing precursors, fail to exhibit a decrease in proliferation unlike wild-type cells and enter the memory compartment before germinal B cell progeny




Genotype
MGI:5461331
cn3
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (57 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:190943 )
N
• mice immunized with NP-CG exhibit normal development of memory B cells
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG

hematopoietic system
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG




Genotype
MGI:5461330
cn4
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JJcl * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (57 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:190943 )
• in memory B cells from mice immunized with NP-CG
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 40 but not day 7
absent germinal center B cells ( J:190943 )
• NP-CG immunized mice fail to generate NP-specific germinal center B cells at day 40
decreased T follicular helper cell number ( J:190943 )
• in mice immunized with NP-CG fail to develop T follicular helper cells at day 7 and 40
abnormal humoral immune response ( J:190943 )
• memory B cells from mice treated with NP-CG produce low affinity antibodies in an IgG1 secondary response unlike wild-type cells

hematopoietic system
abnormal somatic hypermutation frequency ( J:190943 )
• in memory B cells from mice immunized with NP-CG
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 40 but not day 7
absent germinal center B cells ( J:190943 )
• NP-CG immunized mice fail to generate NP-specific germinal center B cells at day 40
decreased T follicular helper cell number ( J:190943 )
• in mice immunized with NP-CG fail to develop T follicular helper cells at day 7 and 40




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory