Phenotypes associated with this allele

• Allele Symbol: Trem1^tm1.1Ahoru
• Allele Name: targeted mutation 1.1, Anatolij Horuzsko
• Allele ID: MGI:5461334
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trem1^tm1.1Ahoru/Trem1^tm1.1Ahoru	C57BL/6-Trem1^tm1.1Ahoru	MGI:5461351

Genotype
MGI:5461351

hm1

• Allelic Composition: Trem1^tm1.1Ahoru/Trem1^tm1.1Ahoru
• Genetic Background: C57BL/6-Trem1^tm1.1Ahoru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased neutrophil cell number ( J:191035 )

• in the liver of DEN-treated mice

decreased monocyte cell number ( J:191035 )

• in the liver and peripheral blood of DEN-treated mice

neoplasm

decreased incidence of tumors by chemical induction ( J:191035 )

• DEN-treated mice develop smaller hepatocellular carcinoma with greater latency compared with wild-type mice

increased tumor latency ( J:191035 )

• in DEN-treated mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191035 )

• DEN-treated mice develop smaller hepatocellular carcinoma with greater latency compared with wild-type mice

decreased susceptibility to injury ( J:191035 )

• during early tumor promotion, diethylnitrosamine (DEN)-treated mice exhibit reduced liver damage and compensatory proliferation compared with wild-type mice

• however, adoptive transfer of wild-type Kupffer cells reverses unresponsiveness to DEN-induced liver injury

hematopoietic system

decreased neutrophil cell number ( J:191035 )

• in the liver of DEN-treated mice

decreased monocyte cell number ( J:191035 )

• in the liver and peripheral blood of DEN-treated mice