Phenotypes associated with this allele

• Allele Symbol: Tnik^tm1Grnt
• Allele Name: targeted mutation 1, Seth G N Grant
• Allele ID: MGI:5461352
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnik^tm1Grnt/Tnik^tm1Grnt	involves: 129P2/OlaHsd * 129S5/SvEvBrd	MGI:5461362

Genotype
MGI:5461362

hm1

• Allelic Composition: Tnik^tm1Grnt/Tnik^tm1Grnt
• Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:190924 )

N • mice exhibit normal NMDAR- and AMPAR-mediated synaptic currents, long-term plasticity (LTP and LTD), and sIPSCs and mIPSCs in the hippocampal CA1 region

N • mice exhibit normal numbers of pyramidal neurons in the CA3 or CA1

abnormal neuron differentiation ( J:190924 )

• impaired neurogenesis in the dentate gyrus

decreased cerebellar granule cell number ( J:190924 )

• in the dentate gyrus

abnormal excitatory postsynaptic potential ( J:190924 )

• evoked field excitatory postsynaptic potential are slightly enhanced at stronger stimulation intensities compared with wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:190924 )

• cells exhibit a decrease in frequency of AMPAR-mediated miniature excitatory postsynaptic currents compared with wild-type cells

enhanced paired-pulse facilitation ( J:190924 )

behavior/neurological

abnormal discrimination learning ( J:190924 )

• in touchscreen tests, mice exhibit impaired pattern discrimination when locations are in close proximity compared with wild-type mice

abnormal object recognition memory ( J:190924 )

• in touchscreen tests, mice exhibit impaired learning associated with an object and its location compared with wild-type mice

increased locomotor activity ( J:190924 )

• mice exhibit increase locomotor activity compared with wild-type mice

• however, GSK3beta antagonist (SB216763) reverses hyperactivity

cellular

abnormal neuron differentiation ( J:190924 )

• impaired neurogenesis in the dentate gyrus