Phenotypes associated with this allele

• Allele Symbol: Stx11^tm1Bupa
• Allele Name: targeted mutation 1, Silvia Bulfone-Paus
• Allele ID: MGI:5461477
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stx11^tm1Bupa/Stx11^tm1Bupa	B6.129-Stx11^tm1Bupa	MGI:5461564

Genotype
MGI:5461564

hm1

• Allelic Composition: Stx11^tm1Bupa/Stx11^tm1Bupa
• Genetic Background: B6.129-Stx11^tm1Bupa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cell-mediated immunity ( J:191103 )

abnormal neutrophil physiology ( J:191103 )

• reduced degranulation of neutrophiles after stimulation with PMA/ionomycin or fMLP

• bone marrow mast cell, bone marrow macrophage, and bone marrow dendritic cell degranulation is normal

abnormal lymphocyte physiology ( J:191103 )

• cytolytic activity of cytotoxic lymphocytes is reduced

impaired natural killer cell mediated cytotoxicity ( J:191103 )

• reduced cytotoxicity after 48 hours of IL-15 treatment and when followed by 6 day incubation with IL-2

abnormal cytokine secretion ( J:191103 )

increased interferon-gamma secretion ( J:191103 )

• increased secretion by both cytotoxic lymphocytes and NK cells

increased tumor necrosis factor secretion ( J:191103 )

• increased secretion by both cytotoxic lymphocytes and NK cells

hematopoietic system

abnormal neutrophil physiology ( J:191103 )

• reduced degranulation of neutrophiles after stimulation with PMA/ionomycin or fMLP

• bone marrow mast cell, bone marrow macrophage, and bone marrow dendritic cell degranulation is normal

abnormal lymphocyte physiology ( J:191103 )

• cytolytic activity of cytotoxic lymphocytes is reduced

impaired natural killer cell mediated cytotoxicity ( J:191103 )

• reduced cytotoxicity after 48 hours of IL-15 treatment and when followed by 6 day incubation with IL-2