Phenotypes associated with this allele

• Allele Symbol: Vdr^tm1.2Sgcg
• Allele Name: targeted mutation 1.2, Songcang Chen
• Allele ID: MGI:5461525
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vdr^tm1.2Sgcg/Vdr^tm1.2Sgcg	involves: 129 * C57BL/6 * CBA * SJL	MGI:5461534
cn2	Vdr^tm1.1Sgcg/Vdr^tm1.2Sgcg Myl2^tm1(cre)Krc/Myl2^+	involves: 129 * C57BL/6 * CBA * SJL	MGI:5461535

Genotype
MGI:5461534

hm1

• Allelic Composition: Vdr^tm1.2Sgcg/Vdr^tm1.2Sgcg
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating atrial natriuretic factor ( J:189471 )

decreased circulating calcium level ( J:189471 )

endocrine/exocrine glands

increased activity of parathyroid ( J:189471 )

cardiovascular system

increased heart left ventricle weight ( J:189471 )

growth/size/body

decreased body weight ( J:189471 )

integument

alopecia ( J:189471 )

Genotype
MGI:5461535

cn2

• Allelic Composition: Vdr^tm1.1Sgcg/Vdr^tm1.2Sgcg; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

cardiovascular system

cardiovascular system phenotype ( J:189471 )

N • untreated and isoflurane-treated mice exhibit normal left ventricular systolic and diastolic function

increased myocardial fiber size ( J:189471 )

• in untreated and isoflurane-treated mice

cardiac hypertrophy ( J:189471 )

• in untreated and isoflurane-treated mice

abnormal heart ventricle morphology ( J:189471 )

• untreated and isoflurane-treated mice exhibit a reduction in end-diastolic volume and end-systolic volume compared with control mice

thick interventricular septum ( J:189471 )

• in untreated and isoflurane-treated mice

increased heart left ventricle weight ( J:189471 )

• in untreated and isoflurane-treated mice

thick ventricular wall ( J:189471 )

• untreated and isoflurane-treated mice exhibit increased thickness of the posterior left ventricular free wall compared with control mice

decreased mean systemic arterial blood pressure ( J:189471 )

decreased systemic arterial diastolic blood pressure ( J:189471 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:189471 )

N • unlike null homozygotes, mice are not hypocalcemic

increased circulating atrial natriuretic factor ( J:189471 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:189471 )

N • unlike null homozygotes, mice do not develop hyperparathyroidism

muscle

increased myocardial fiber size ( J:189471 )

• in untreated and isoflurane-treated mice

growth/size/body

cardiac hypertrophy ( J:189471 )

• in untreated and isoflurane-treated mice