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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd28tm1.1Huen
targeted mutation 1.1, Thomas Hunig
MGI:5461540
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd28tm1.1Huen/Cd28tm1.1Huen
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6 * C57BL/6NTac MGI:5461543


Genotype
MGI:5461543
cn1
Allelic
Composition		 Cd28tm1.1Huen/Cd28tm1.1Huen
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1.1Huen mutation (0 available); any Cd28 mutation (52 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (992 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased regulatory T cell number ( J:191101 )
• after 1 week, tamoxifen-treated mice exhibit decreased regulatory T cell number compared with control mice that is thymus independent and associated with reduced cell proliferation
abnormal regulatory T cell physiology ( J:191101 )
• regulatory T cells from tamoxifen-treated mice exhibit reduced suppression function and a 2-fold reduction in proliferation compared with wild-type cells

hematopoietic system
decreased regulatory T cell number ( J:191101 )
• after 1 week, tamoxifen-treated mice exhibit decreased regulatory T cell number compared with control mice that is thymus independent and associated with reduced cell proliferation
abnormal regulatory T cell physiology ( J:191101 )
• regulatory T cells from tamoxifen-treated mice exhibit reduced suppression function and a 2-fold reduction in proliferation compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory