Phenotypes associated with this allele

• Allele Symbol: Tbx18^{tm2.1(cre)Sev}
• Allele Name: targeted mutation 2.1, Sylvia Evans
• Allele ID: MGI:5461544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox2^tm4.1Skn/Sox2^tm4.1Skn Tbx18^tm2.1(cre)Sev/Tbx18^+	involves: 129S1/Sv	MGI:5461657

Genotype
MGI:5461657

cn1

• Allelic Composition: Sox2^tm4.1Skn/Sox2^tm4.1Skn; Tbx18^{tm2.1(cre)Sev}/Tbx18⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:191082 )

N

abnormal hair growth ( J:191082 )

• hair shaft outgrowth is markedly delayed after birth compared to controls (heterozygotes); guard hair shaft lengths are significantly shorter than controls at P8 and later stages, indicating reduced outgrowth speed

• guard and awl/auchene hairs are 20-55% shorter in mutants, while zigzag hairs are comparable to heterozygous controls

• proliferation and differentiation of matrix progenitor cells are normal

• BrdU labeling of matrix cells at P5 indicates that, while proliferation is normal in mutants, the rate of transition into the hair shaft area is delayed; delay in migration is observed up to 48 hours after BrdU injection; upward movement of differentiation matrix progenitor cells is impaired

• migration of hair shaft progenitors in mutant zigzag follicles is much slower than in control guard hairs; migration speed of mutant guard hairs is reduced and becomes comparable to the speed of migration of control or mutant zigzag follicles