Phenotypes associated with this allele

• Allele Symbol: Appl1^tm1Ymli
• Allele Name: targeted mutation 1, Yiming Li
• Allele ID: MGI:5461700
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Appl1^tm1Ymli/Appl1^tm1Ymli	involves: 129S1/Sv * C57BL/6J	MGI:5461706

Genotype
MGI:5461706

hm1

• Allelic Composition: Appl1^tm1Ymli/Appl1^tm1Ymli
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased vasoconstriction ( J:189487 )

• mice fed a high fat diet exhibit increased insulin-induced ET-1-dependent vasoconstriction compared with wild-type mice

decreased vasodilation ( J:189487 )

• whether mice are fed standard chow or a high fat diet, arteries exhibit impaired insulin-induced relaxation compared with wild-type mice

muscle

increased vasoconstriction ( J:189487 )

• mice fed a high fat diet exhibit increased insulin-induced ET-1-dependent vasoconstriction compared with wild-type mice

decreased vasodilation ( J:189487 )

• whether mice are fed standard chow or a high fat diet, arteries exhibit impaired insulin-induced relaxation compared with wild-type mice