Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-APPL1)#Ymli
• Allele Name: transgene insertion, Yiming Li
• Allele ID: MGI:5461701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-APPL1)#Ymli/0	involves: C57BL/6 * CBA	MGI:5461705

Genotype
MGI:5461705

tg1

• Allelic Composition: Tg(CAG-APPL1)#Ymli/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased vasoconstriction ( J:189487 )

• mice fed a high fat diet exhibit impaired insulin-induced ET-1-dependent vasoconstriction compared with wild-type mice

abnormal vasodilation ( J:189487 )

• mice exhibit impaired high fat-diet-induced impairment in insulin-induced relaxation that is reversed to vasoconstriction compared with wild-type mice

increased vasodilation ( J:189487 )

• during contractions to the prostaglandin H2 analog U46619, the magnitude of insulin-induce relaxation is greater than in wild-type mice

• however, maximal relaxation response to supraphysiological doses of insulin is normal

muscle

decreased vasoconstriction ( J:189487 )

• mice fed a high fat diet exhibit impaired insulin-induced ET-1-dependent vasoconstriction compared with wild-type mice

abnormal vasodilation ( J:189487 )

• mice exhibit impaired high fat-diet-induced impairment in insulin-induced relaxation that is reversed to vasoconstriction compared with wild-type mice

increased vasodilation ( J:189487 )

• during contractions to the prostaglandin H2 analog U46619, the magnitude of insulin-induce relaxation is greater than in wild-type mice

• however, maximal relaxation response to supraphysiological doses of insulin is normal

increased skeletal muscle cell glucose uptake ( J:230004 )

• increased glucose uptake in extensor digitorum longus or soleus muscles compared with control muscles

cellular

increased skeletal muscle cell glucose uptake ( J:230004 )

• increased glucose uptake in extensor digitorum longus or soleus muscles compared with control muscles