Phenotypes associated with this allele

• Allele Symbol: Trpc3^tm1.1Bmil
• Allele Name: targeted mutation 1.1, Barbara A Miller
• Allele ID: MGI:5461709
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil	involves: FVB/N	MGI:5461712
cx2	Trpc2^tm1Dlc/Trpc2^tm1Dlc Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil	involves: 129S1/Sv * FVB/N	MGI:5461713

Genotype
MGI:5461712

hm1

• Allelic Composition: Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:189490 )

N • all hematopoietic parameters are normal

Genotype
MGI:5461713

cx2

• Allelic Composition: Trpc2^tm1Dlc/Trpc2^tm1Dlc; Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil
• Genetic Background: involves: 129S1/Sv * FVB/N

hematopoietic system

abnormal erythroblast morphology ( J:189490 )

• in response to oxidative stress, erythroblasts exhibit decreased intracellular calcium compared with wild-type cells

increased hematocrit ( J:189490 )

decreased mean corpuscular hemoglobin concentration ( J:189490 )

increased mean corpuscular volume ( J:189490 )

abnormal erythrocyte physiology ( J:189490 )

• red blood cells are resistant to phenylhydrazine-induced hemolysis compared with wild-type cells