All Phenotypes Hdc<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hdc⁺
wild type
MGI:5461820

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hdc^tm1Nagy/Hdc⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5697374
cn2	Gabrg2^tm1Wul/Gabrg2^tm1Wul Hdc^{tm1.1(icre)Wwis}/Hdc⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5461821
cn3	Gabbr1^tm2Bet/Gabbr1^tm2Bet Hdc^{tm1.1(icre)Wwis}/Hdc⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5461822

Allelic Composition	Hdc^tm1Nagy/Hdc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdc^tm1Nagy mutation (0 available); any Hdc mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:220412 )

N	• mice show normal baseline locomotion, exploratory rearing, and center occupancy in the open field, and no evident spontaneous motor stereotypies

abnormal behavioral response to amphetamine ( J:220412 )

• locomotor activation is attenuated after amphetamine administration

• mutants show increased motor stereotypies compared to controls after a high dose of amphetamine administration, consisting of repetitive focused sniffing and orofacial movements

• pretreatment with haloperidol, a dopamine D2 receptor antagonist, eliminates the stereotypies induced by amphetamine

• mice infused with histamine intracerebroventricularly immediately before administration of amphetamine show delayed and reduced amplitude of stereotypy

nervous system

abnormal substantia nigra morphology ( J:220412 )

• mice exhibit higher dopamine D2 and D3 receptor density in the substantia nigra than controls

abnormal striatum morphology ( J:220412 )

• mice exhibit a reduction in dopamine D2 and D3 receptor density in the dorsal striatum

decreased prepulse inhibition ( J:220412 )

• mice exhibit a deficit in auditory PPI at three prepulse intensities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Gilles de la Tourette syndrome		DOID:11119	OMIM:137580	J:220412

Allelic Composition	Gabrg2^tm1Wul/Gabrg2^tm1Wul Hdc^{tm1.1(icre)Wwis}/Hdc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2^tm1Wul mutation (1 available); any Gabrg2 mutation (41 available)
Hdc^{tm1.1(icre)Wwis} mutation (1 available); any Hdc mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron physiology ( J:188103 )

• tuberomammillary nucleus (TMN) neurons lacking GABAA receptors are more excitable than control neurons; more action potentials (APs) are produced for a given current injection and current needed to reach threshold for AP generation is reduced significantly

• tuberomammillary nucleus neurons have increased membrane time constants compared to control neurons

abnormal GABA-mediated receptor currents ( J:188103 )

• whole cell voltage-clamped mutant neurons in the ventral tuberomammillary (VTM) nucleus lack fast GABAA receptor-mediated IPSCs, but are IPSCs are observed in controls

• in dorsal lateral geniculate (DLG) nucleus slice preparations, only 30% of neurons exhibit GABAergic IPSCs compared to most neurons tested in control slices

abnormal inhibitory postsynaptic currents ( J:188103 )

behavior/neurological

behavior/neurological phenotype ( J:188103 )

• mice appear indistinguishable from controls in health, behavior and appearance

• total sleep-wake time, EEG power spectrum, and duration of REM and non-REM (NREM) periods during the 24 hour cycle do not differ from controls

• habituation to a new environment is not different from controls

• propofol-induced loss of righting reflex (LORR) is not different from controls

Allelic Composition	Gabbr1^tm2Bet/Gabbr1^tm2Bet Hdc^{tm1.1(icre)Wwis}/Hdc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabbr1^tm2Bet mutation (0 available); any Gabbr1 mutation (71 available)
Hdc^{tm1.1(icre)Wwis} mutation (1 available); any Hdc mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:188103 )

N	• mice appear indistinguishable from controls in health, behavior and appearance • EEG or sleep-wake parameters during the 24 hour cycle do not differ from controls • propofol-induced loss of righting reflex (LORR) is not different from controls

abnormal habituation to a new environment ( J:188103 )

• level of arousal (time spent in the wake phase) remains elevated for a longer period in mutants in response to a change of environment, compared to controls

nervous system

abnormal neuron physiology ( J:188103 )

• tuberomammillary nucleus neurons in brain slices from mutant animals are not hyperpolarized by propofol treatment, as observed in control neurons

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