Phenotypes associated with this allele

• Allele Symbol: Stard13^tm1.1Fms
• Allele Name: targeted mutation 1.1, Francesca M Spagnoli
• Allele ID: MGI:5461853
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stard13^tm1.1Fms/Stard13^tm1.1Fms Tg(Pdx1-cre)89.1Dam/0	involves: C57BL/6 * CBA * SJL	MGI:5461855

Genotype
MGI:5461855

cn1

• Allelic Composition: Stard13^tm1.1Fms/Stard13^tm1.1Fms; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas development ( J:191071 )

• at E12.5 branching structures fail to form, although pancreatic fate is normally specified

• at E12.5 but not at E11.5 proliferation is decreased mainly due to a decrease in proliferation of pancreatic progenitor cells

• epithelial cells fail to remodel and instead remain stratified with cuboidal shape and disorderly arrangement possibly due to a defect in actomyosin cytoskeletal organization

• both endocrine and exocrine cells similarly affected

• at E16.5 ducts and acini appear as malformed large cellular aggregates

• cultured explants fail to form tubular aggregates under conditions where wild-type explants form aggregates; however, in the presence of C3 ribosyltransferase mutant explants will form tubular aggregates

pancreas hypoplasia ( J:191071 )

growth/size/body

postnatal growth retardation ( J:191071 )

homeostasis/metabolism

impaired glucose tolerance ( J:191071 )

• show a slower and delayed return to basal levels after glucose challenge