Phenotypes associated with this allele

• Allele Symbol: Tada3^tm1.1Viba
• Allele Name: targeted mutation 1.1, Vimla Band
• Allele ID: MGI:5462193
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tada3^tm1.1Viba/Tada3^tm1.1Viba	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5462196
cn2	Tada3^tm1.1Viba/Tada3^tm1.1Viba	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5462197

Genotype
MGI:5462196

hm1

• Allelic Composition: Tada3^tm1.1Viba/Tada3^tm1.1Viba
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:190249 )

• mice are viable and fertile and exhibit no gross abnormalities

Genotype
MGI:5462197

cn2

• Allelic Composition: Tada3^tm1.1Viba/Tada3^tm1.1Viba
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

cellular

abnormal mitosis ( J:190249 )

• mouse embryonic fibroblasts infected with a cre-expressing adenovirus exhibit delay in G1 to S and G2/M to G1 progression compared with wild-type cells

decreased fibroblast proliferation ( J:190249 )

• in mouse embryonic fibroblasts infected with a cre-expressing adenovirus

• however, proliferation is rescued by over-expression of the human cDNA or knock-down of Cdkn1b