All Phenotypes Thbd<tm1.1(THBD)Sltz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thbd^{tm1.1(THBD)Sltz}
targeted mutation 1.1, Steven R Lentz
MGI:5462218

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}	129S/SvEv(FVB)-Thbd^{tm1.1(THBD)Sltz}	MGI:5462230
hm2	Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}	B6.129S(FVB)-Thbd^{tm1.1(THBD)Sltz}	MGI:5462229
ht3	Thbd^{tm1.1(THBD)Sltz}/Thbd⁺	either: 129S/SvEv(FVB)-Thbd^{tm1.1(THBD)Sltz} or B6.129S(FVB)-Thbd^{tm1.1(THBD)Sltz}	MGI:5462231
cx4	Apoe^tm1Unc/Apoe^tm1Unc Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}	B6.129(FVB)-Thbd^{tm1.1(THBD)Sltz} Apoe^tm1Unc	MGI:5462232

Allelic Composition	Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}
Genetic Background	129S/SvEv(FVB)-Thbd^{tm1.1(THBD)Sltz}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbd^{tm1.1(THBD)Sltz} mutation (0 available); any Thbd mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:191461 )

• fewer than expected mice are present at weaning

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:191461 )

• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples

Allelic Composition	Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}
Genetic Background	B6.129S(FVB)-Thbd^{tm1.1(THBD)Sltz}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbd^{tm1.1(THBD)Sltz} mutation (0 available); any Thbd mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:191461 )

• fewer than expected mice are present at E17.5 and weaning

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:191461 )

• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples

abnormal response to injury ( J:191461 )

• after photochemical injury, the mean time to stable occlusion is decreased compared to in wild-type mice

Allelic Composition	Thbd^{tm1.1(THBD)Sltz}/Thbd⁺
Genetic Background	either: 129S/SvEv(FVB)-Thbd^{tm1.1(THBD)Sltz} or B6.129S(FVB)-Thbd^{tm1.1(THBD)Sltz}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbd^{tm1.1(THBD)Sltz} mutation (0 available); any Thbd mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:191461 )

• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}
Genetic Background	B6.129(FVB)-Thbd^{tm1.1(THBD)Sltz} Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Thbd^{tm1.1(THBD)Sltz} mutation (0 available); any Thbd mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:191461 )

N	• mice fed a high fat diet exhibit the same increase in total cholesterol, atherosclerotic lesion area and time to occlusion of the carotid artery following photochemical injury as Apoe^tm1Unc homozygotes

abnormal enzyme/coenzyme activity ( J:191461 )

• mice fed a high fat diet exhibit decreased amount of circulating activated protein C compared with Apoe^tm1Unc homozygotes

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