About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Thbdtm1(THBD)Sltz
targeted mutation 1, Steven R Lentz
MGI:5462220
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz 129S/SvEv-Thbdtm1(THBD)Sltz MGI:5462226
hm2
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz involves: 129S/SvEv * C57BL/6 MGI:5462227
ht3
Thbdtm1(THBD)Sltz/Thbd+ either: 129S/SvEv-Thbdtm1(THBD)Sltz or (involves: 129S/SvEv * C57BL/6) MGI:5462228


Genotype
MGI:5462226
hm1
Allelic
Composition
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic
Background
129S/SvEv-Thbdtm1(THBD)Sltz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

homeostasis/metabolism
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples




Genotype
MGI:5462227
hm2
Allelic
Composition
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at E17.5 and weaning

homeostasis/metabolism
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples




Genotype
MGI:5462228
ht3
Allelic
Composition
Thbdtm1(THBD)Sltz/Thbd+
Genetic
Background
either: 129S/SvEv-Thbdtm1(THBD)Sltz or (involves: 129S/SvEv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory