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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Thbdtm1(THBD)Sltz
targeted mutation 1, Steven R Lentz
MGI:5462220
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz 129S/SvEv-Thbdtm1(THBD)Sltz MGI:5462226
hm2
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz involves: 129S/SvEv * C57BL/6 MGI:5462227
ht3
Thbdtm1(THBD)Sltz/Thbd+ either: 129S/SvEv-Thbdtm1(THBD)Sltz or (involves: 129S/SvEv * C57BL/6) MGI:5462228


Genotype
MGI:5462226
hm1
Allelic
Composition
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic
Background
129S/SvEv-Thbdtm1(THBD)Sltz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

homeostasis/metabolism
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples




Genotype
MGI:5462227
hm2
Allelic
Composition
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at E17.5 and weaning

homeostasis/metabolism
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples




Genotype
MGI:5462228
ht3
Allelic
Composition
Thbdtm1(THBD)Sltz/Thbd+
Genetic
Background
either: 129S/SvEv-Thbdtm1(THBD)Sltz or (involves: 129S/SvEv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory