Phenotypes associated with this allele

• Allele Symbol: Ccl2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5462245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl2^tm1Lex/Ccl2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5462248

Genotype
MGI:5462248

hm1

• Allelic Composition: Ccl2^tm1Lex/Ccl2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired macrophage chemotaxis ( J:191510 )

N • mice exhibit impaired recruitment of macrophages from mice homozygous for Ccr2^tm1Mae compared recruitment of wild-type cells

N • obese mice impaired recruitment of macrophages from lean wild-type mice compared with obese wild-type mice

immune system

impaired macrophage chemotaxis ( J:191510 )

N • mice exhibit impaired recruitment of macrophages from mice homozygous for Ccr2^tm1Mae compared recruitment of wild-type cells

N • obese mice impaired recruitment of macrophages from lean wild-type mice compared with obese wild-type mice

hematopoietic system

impaired macrophage chemotaxis ( J:191510 )

N • mice exhibit impaired recruitment of macrophages from mice homozygous for Ccr2^tm1Mae compared recruitment of wild-type cells

N • obese mice impaired recruitment of macrophages from lean wild-type mice compared with obese wild-type mice