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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Traf3ip2tm2Sbn
targeted mutation 2, Ulrich Siebenlist
MGI:5462251
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:5462351
cx2
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2+ 		involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:5462356


Genotype
MGI:5462351
cn1
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm2Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:191090 )
• mutants exhibit an increase in percentage and the total number of germinal center B cells compared to wild-type mice, although the total number of germinal center B cells is lower than in Fcgr2b homozygotes (that are also heterozygous for the floxed Traf3ip2 allele)
glomerulonephritis ( J:191090 )
• develop glomerulonephritis comparable to single Fcgr2b homozygotes

hematopoietic system
increased germinal center B cell number ( J:191090 )
• mutants exhibit an increase in percentage and the total number of germinal center B cells compared to wild-type mice, although the total number of germinal center B cells is lower than in Fcgr2b homozygotes (that are also heterozygous for the floxed Traf3ip2 allele)

renal/urinary system
glomerulonephritis ( J:191090 )
• develop glomerulonephritis comparable to single Fcgr2b homozygotes




Genotype
MGI:5462356
cx2
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2+
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm2Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased germinal center B cell number ( J:191090 )
• increase in the total number of germinal center B cells
increased plasma cell number ( J:191090 )
• increase in the percentage and number of plasma cells

immune system
increased germinal center B cell number ( J:191090 )
• increase in the total number of germinal center B cells
increased plasma cell number ( J:191090 )
• increase in the percentage and number of plasma cells

growth/size/body
enlarged spleen ( J:191090 )
increased spleen weight ( J:191090 )
spleen hyperplasia ( J:191090 )




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory