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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kif19atm1Noh
targeted mutation 1, Nobutaka Hirokawa
MGI:5463445
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kif19atm1Noh/Kif19atm1Noh involves: 129S6/SvEvTac * C57BL/6J MGI:5463446
ht2
Kif19atm1Noh/Kif19a+ involves: 129S6/SvEvTac * C57BL/6J MGI:5463448


Genotype
MGI:5463446
hm1
Allelic
Composition
Kif19atm1Noh/Kif19atm1Noh
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif19atm1Noh mutation (0 available); any Kif19a mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born at the expected Mendelian ratio but few survivors at 4 weeks of age

reproductive system
• lumens are filled with mucus and debris
• debris contains nuclear structures suggesting it is made up of dead cells
• a 2.5 fold increase in cilia length
• movement of oviduct ciliary tips is abnormal, disorganized, and fails to generate proper fluid flow
• apparently caused by fallopian tube obstruction

nervous system
• a 1.8 fold increase in cilia length
• in males and females

respiratory system
• a 1.4 fold increase in cilia length in the trachea
• a 1.4 fold increase in cilia length

growth/size/body

cellular
• a 1.8 fold increase in cilia length
• a 2.5 fold increase in cilia length
• a 1.4 fold increase in cilia length in the trachea




Genotype
MGI:5463448
ht2
Allelic
Composition
Kif19atm1Noh/Kif19a+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif19atm1Noh mutation (0 available); any Kif19a mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• a 1.4 fold increase in cilia length

cellular
• a 1.4 fold increase in cilia length





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory