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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vps52tm1.2Kab
targeted mutation 1.2, Kuniya Abe
MGI:5463590
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vps52tm1.2Kab/Vps52tm1.2Kab involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA MGI:5464112
cn2
Vps52tm1.1Kab/Vps52tm1.2Kab
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL * C57BL/6 * CBA * DBA MGI:5464113
cx3
Vps52tm1.2Kab/tw5 Vps52t-w5 involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA MGI:5464110


Genotype
MGI:5464112
hm1
Allelic
Composition
Vps52tm1.2Kab/Vps52tm1.2Kab
Genetic
Background
involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps52tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• early embryonic lethality similar to mice homozygous for tw5




Genotype
MGI:5464113
cn2
Allelic
Composition
Vps52tm1.1Kab/Vps52tm1.2Kab
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: C57BL * C57BL/6 * CBA * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Vps52tm1.1Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• vascular congestion is detected in the yolk sac at E8.5
• severe disruption of normal vascular patterning during yolk sac vasculogenesis
• at E9.5 the rostral half of the embryo is formed almost normally but development of the caudal half is retarded

cardiovascular system
• vascular congestion is detected in the yolk sac at E8.5
• severe disruption of normal vascular patterning during yolk sac vasculogenesis




Genotype
MGI:5464110
cx3
Allelic
Composition
Vps52tm1.2Kab/tw5 Vps52t-w5
Genetic
Background
involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
tw5 mutation (3 available); any t mutation (19 available)
Vps52tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52t-w5 mutation (0 available); any Vps52 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E6.5 all embryos show embryonic ectoderm defects typical of mice homozygous for tw5





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory