All Phenotypes Vps52<tm1.2Kab> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vps52^tm1.2Kab
targeted mutation 1.2, Kuniya Abe
MGI:5463590

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps52^tm1.2Kab/Vps52^tm1.2Kab	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	MGI:5464112
cn2	Vps52^tm1.1Kab/Vps52^tm1.2Kab Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: C57BL * C57BL/6 * CBA * DBA	MGI:5464113
cx3	Vps52^tm1.2Kab/t^w5 Vps52^t-w5	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA	MGI:5464110

Allelic Composition	Vps52^tm1.2Kab/Vps52^tm1.2Kab
Genetic Background	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:190873 )

• early embryonic lethality similar to mice homozygous for t^w5

Allelic Composition	Vps52^tm1.1Kab/Vps52^tm1.2Kab Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL * C57BL/6 * CBA * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Vps52^tm1.1Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:190873 )

embryo

abnormal vitelline vasculature morphology ( J:190873 )

• vascular congestion is detected in the yolk sac at E8.5

disorganized yolk sac vascular plexus ( J:190873 )

• severe disruption of normal vascular patterning during yolk sac vasculogenesis

abnormal embryonic tissue morphology ( J:190873 )

• at E9.5 the rostral half of the embryo is formed almost normally but development of the caudal half is retarded

cardiovascular system

abnormal vitelline vasculature morphology ( J:190873 )

• vascular congestion is detected in the yolk sac at E8.5

disorganized yolk sac vascular plexus ( J:190873 )

• severe disruption of normal vascular patterning during yolk sac vasculogenesis

Allelic Composition	Vps52^tm1.2Kab/t^w5 Vps52^t-w5
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52^t-w5 mutation (0 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal ectoderm development ( J:190873 )

• at E6.5 all embryos show embryonic ectoderm defects typical of mice homozygous for t^w5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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