Phenotypes associated with this allele

• Allele Symbol: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi
• Allele Name: transgene insertion 1, Natalio Garbi
• Allele ID: MGI:5463655
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Itgax-HBEGF/OVA/EGFP)1Garbi/0	C57BL/6-Tg(Itgax-HBEGF/OVA/EGFP)1Garbi	MGI:5476627

Genotype
MGI:5476627

tg1

• Allelic Composition: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi/0
• Genetic Background: C57BL/6-Tg(Itgax-HBEGF/OVA/EGFP)1Garbi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:194800 )

• neutrophilia is quantitatively similar to that observed in Tg(Itgax-DTR/OVA/EGFP)1Garbi animals after diphtheria toxin treatment, although neutrophilia declined after 72 hours

• intrarenal polymorphonuclear neutrophil (PMN) numbers are also similar

• at a dose of 40 ng DT/g body weight, neutrophilia persisted beyond 72 hours

decreased dendritic cell number ( J:194800 )

• depletion of kidney dendritic cells is quantitatively similar to that observed in Tg(Itgax-DTR/OVA/EGFP)1Garbi animals after diphtheria toxin treatment

immune system

increased neutrophil cell number ( J:194800 )

• neutrophilia is quantitatively similar to that observed in Tg(Itgax-DTR/OVA/EGFP)1Garbi animals after diphtheria toxin treatment, although neutrophilia declined after 72 hours

• intrarenal polymorphonuclear neutrophil (PMN) numbers are also similar

• at a dose of 40 ng DT/g body weight, neutrophilia persisted beyond 72 hours

decreased dendritic cell number ( J:194800 )

• depletion of kidney dendritic cells is quantitatively similar to that observed in Tg(Itgax-DTR/OVA/EGFP)1Garbi animals after diphtheria toxin treatment

abnormal susceptibility to infection ( J:194800 )

• in contrast to infected Tg(Itgax-DTR/OVA/EGFP)1Garbi animals, bacterial clearance (of uropathogenic E. coli) is improved 1 day after dendritic cell depletion