Phenotypes associated with this allele

• Allele Symbol: Uimc1^tm1.2Amj
• Allele Name: targeted mutation 1.2, Anton M Jetten
• Allele ID: MGI:5463917
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uimc1^tm1.2Amj/Uimc1^tm1.2Amj	involves: BALB/cJ * C57BL/6	MGI:5463921
cx2	Trp53^tm1Tyj/Trp53^tm1Tyj Uimc1^tm1.2Amj/Uimc1^tm1.2Amj	involves: 129S2/SvPas * BALB/cJ * C57BL/6	MGI:5463922
cx3	Trp53^tm1Tyj/Trp53^+ Uimc1^tm1.2Amj/Uimc1^tm1.2Amj	involves: 129S2/SvPas * BALB/cJ * C57BL/6	MGI:5463923

Genotype
MGI:5463921

hm1

• Allelic Composition: Uimc1^tm1.2Amj/Uimc1^tm1.2Amj
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191827 )

• when exposed to DMBA weekly for 4 weeks tumor free survival time is reduced compared to wild-type controls

neoplasm

increased incidence of tumors by chemical induction ( J:191827 )

• when exposed to DMBA weekly for 4 weeks 40% of mice develop mammary tumors compared to only 5% of wild-type controls

• however, no difference in the induction of lymphomas or ovarian carcinomas by DMBA is detected

increased lymphoma incidence ( J:191827 )

• by 20 months of age, 52% of mice develop either thymic or splenic lymphomas

• occasionally, lymphomas infiltrate nonlymphoid tissues

increased T cell derived lymphoma incidence ( J:191827 )

increased B cell derived lymphoma incidence ( J:191827 )

increased incidence of tumors by ionizing radiation induction ( J:191827 )

• after exposure to 6 Gy ionizing radiation about 18% (4 of 22) develop thymic lymphomas compared to only 4.7% (1 of 21) wild-type mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191827 )

• when exposed to DMBA weekly for 4 weeks tumor free survival time is reduced compared to wild-type controls

increased incidence of tumors by chemical induction ( J:191827 )

• when exposed to DMBA weekly for 4 weeks 40% of mice develop mammary tumors compared to only 5% of wild-type controls

• however, no difference in the induction of lymphomas or ovarian carcinomas by DMBA is detected

cellular

abnormal cell cycle checkpoint function ( J:191827 )

• prolonged G2-M arrest in response to ionizing irradiation

decreased fibroblast proliferation ( J:191827 )

• the doubling time of MEFs increases more rapidly upon passing compared to wild-type MEFs and cultures contain fewer proliferating cells

early cellular replicative senescence ( J:191827 )

• by passage 3 MEF cultures contain more giant non-dividing senescent cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:191827 )

immune system

increased T cell derived lymphoma incidence ( J:191827 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:191827 )

Genotype
MGI:5463922

cx2

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj; Uimc1^tm1.2Amj/Uimc1^tm1.2Amj
• Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

mortality/aging

decreased tumor-free survival time ( J:191827 )

• significant decrease in tumor free survival

Genotype
MGI:5463923

cx3

• Allelic Composition: Trp53^tm1Tyj/Trp53⁺; Uimc1^tm1.2Amj/Uimc1^tm1.2Amj
• Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

neoplasm

increased tumor growth/size ( J:191827 )

• weight of ionizing radiation induced thymic lymphomas is increased compared to mutant mice wild-type for Uimc1

increased lymphoma incidence ( J:191827 )

• 78.5% of mice (11 of 14) develop thymic lymphomas after exposure to ionizing radiation

increased incidence of tumors by ionizing radiation induction ( J:191827 )

• 78.5% of mice (11 of 14) develop thymic lymphomas after exposure to ionizing radiation