About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmintm1.2Jhh
targeted mutation 1.2, Jorg Heierhorst
MGI:5463937
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Trp53tm1Brn/Trp53tm1Brn
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5463974
cn2
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S1/Sv * BALB/c * C57BL/6 MGI:5463975
cn3
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 MGI:5463972
cn4
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5463971


Genotype
MGI:5463974
cn1
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Trp53tm1Brn/Trp53tm1Brn
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:191832 )
• in the spleen but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
decreased immature B cell number ( J:191832 )
• in the bone marrow but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

hematopoietic system
decreased B cell number ( J:191832 )
• in the spleen but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
decreased immature B cell number ( J:191832 )
• in the bone marrow but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice




Genotype
MGI:5463975
cn2
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:191832 )
N
• B cell development is rescued compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
enlarged spleen ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased spleen weight ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased B cell number ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased immature B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased pre-B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

hematopoietic system
enlarged spleen ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased spleen weight ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased B cell number ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased immature B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased pre-B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

growth/size/body
enlarged spleen ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased spleen weight ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice




Genotype
MGI:5463972
cn3
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small spleen size in Atmintm1.2Jhh/Atmintm1.2Jhh/ Cd79atm1(cre)Reth/Cd79a+ mice

immune system
abnormal B cell differentiation ( J:191832 )
• impaired in a cell-intrinsic manner
• not rescued by provision of a prearranged BCR
decreased immature B cell number ( J:191832 )
• more than 7-fold in the bone marrow
decreased mature B cell number ( J:191832 )
• more than 7-fold in the spleen
decreased pre-B cell number ( J:191832 )
• 3-fold in the bone marrow
small spleen ( J:191832 )
• 2-fold
abnormal B cell physiology ( J:191832 )
• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells

hematopoietic system
abnormal B cell differentiation ( J:191832 )
• impaired in a cell-intrinsic manner
• not rescued by provision of a prearranged BCR
decreased immature B cell number ( J:191832 )
• more than 7-fold in the bone marrow
decreased mature B cell number ( J:191832 )
• more than 7-fold in the spleen
decreased pre-B cell number ( J:191832 )
• 3-fold in the bone marrow
small spleen ( J:191832 )
• 2-fold
abnormal B cell physiology ( J:191832 )
• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells




Genotype
MGI:5463971
cn4
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:191832 )
N
• pIpC-treated mice exhibit normal T cell development
decreased lymphocyte cell number ( J:191832 )
• 2-fold in pIpC-treated mice
decreased B cell number ( J:191832 )
• in pIpC-treated mice
decreased mature B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice
• 2-fold in the spleen of pIpC-treated mice
decreased pre-B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice

hematopoietic system
decreased erythrocyte cell number ( J:191832 )
• modest in pIpC-treated mice
decreased lymphocyte cell number ( J:191832 )
• 2-fold in pIpC-treated mice
decreased B cell number ( J:191832 )
• in pIpC-treated mice
decreased mature B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice
• 2-fold in the spleen of pIpC-treated mice
decreased pre-B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory