Phenotypes associated with this allele

• Allele Symbol: Cenpo^{tm1b(KOMP)Mbp}
• Allele Name: targeted mutation 1b, Mouse Biology Program, UC Davis
• Allele ID: MGI:5463969
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cenpo^tm1b(KOMP)Mbp/Cenpo^tm1b(KOMP)Mbp	B6N(Cg)-Cenpo^tm1b(KOMP)Mbp/J	MGI:5630960
ht2	Cenpo^tm1b(KOMP)Mbp/Cenpo^+	B6N(Cg)-Cenpo^tm1b(KOMP)Mbp/J	MGI:5630959

Genotype
MGI:5630960

hm1

• Allelic Composition: Cenpo^{tm1b(KOMP)Mbp}/Cenpo^{tm1b(KOMP)Mbp}
• Genetic Background: B6N(Cg)-Cenpo^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD00518_3_C02

Data Sources

IMPC Data for Cenpo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cenpo^{tm1b(KOMP)Mbp}/Cenpo^{tm1b(KOMP)Mbp} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder at E7.5, but no primitive streak or hallmarks of gastrulation are seen indicating arrest prior to gastrulation.

embryo

failure to gastrulate ( J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5630959

ht2

• Allelic Composition: Cenpo^{tm1b(KOMP)Mbp}/Cenpo⁺
• Genetic Background: B6N(Cg)-Cenpo^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD00518_3_C02

Data Sources

IMPC Data for Cenpo

behavior/neurological

hyperactivity ( J:211773 )

IMPC - JAX

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

♀

IMPC - JAX

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - JAX

decreased circulating free fatty acids level ( J:211773 )

IMPC - JAX

decreased circulating triglyceride level ( J:211773 )

♂

IMPC - JAX

decreased circulating calcium level ( J:211773 )

♀

IMPC - JAX

decreased circulating iron level ( J:211773 )

♀

IMPC - JAX

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - JAX