Phenotypes associated with this allele

• Allele Symbol: Rr123^tm1.1Vbo
• Allele Name: targeted mutation 1.1, Harald von Boehmer
• Allele ID: MGI:5463979
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr123^tm1.1Vbo/Rr123^tm1.1Vbo	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5463980

Genotype
MGI:5463980

hm1

• Allelic Composition: Rr123^tm1.1Vbo/Rr123^tm1.1Vbo
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:191815 )

N • neonates exhibit normal thymic T regulatory cell development

N • young adult mice exhibit normal T regulatory cell frequencies

N • mice exhibit normal susceptibility to DSS-induced colitis

abnormal regulatory T cell morphology ( J:191815 )

• in response to TGF-beta treatment (especially at low concentrations), naive T cells exhibit reduced conversion to regulatory T cells compared with wild-type cells

increased regulatory T cell number ( J:191815 )

• at 4 weeks in the Peyer's patch and lamina propria lymphocyte

hematopoietic system

abnormal regulatory T cell morphology ( J:191815 )

• in response to TGF-beta treatment (especially at low concentrations), naive T cells exhibit reduced conversion to regulatory T cells compared with wild-type cells

increased regulatory T cell number ( J:191815 )

• at 4 weeks in the Peyer's patch and lamina propria lymphocyte