Phenotypes associated with this allele

• Allele Symbol: Cyp11a1^tm1.1Bcc
• Allele Name: targeted mutation 1.1, Bon-Chu Chung
• Allele ID: MGI:5464022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp11a1^tm1.1Bcc/Cyp11a1^tm1.1Bcc	B6.129(FVB)-Cyp11a1^tm1.1Bcc	MGI:5464023

Genotype
MGI:5464023

hm1

• Allelic Composition: Cyp11a1^tm1.1Bcc/Cyp11a1^tm1.1Bcc
• Genetic Background: B6.129(FVB)-Cyp11a1^tm1.1Bcc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:191801 )

homeostasis/metabolism

increased circulating adrenocorticotropin level ( J:191801 )

• 10-fold at E18.5

decreased adrenaline level ( J:191801 )

• undetectable adrenal adrenaline

decreased noradrenaline level ( J:191801 )

• reduced adrenal noradrenaline

abnormal corticosterone level ( J:191801 )

• decreased in the adrenal

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:191801 )

• disorganized at E16.5 with no separation of the cortex and medulla

• distribution of proliferating cells is random at E16.5 and E18.

• lipid droplets are larger than in wild-type adrenal and are randomly distributed at E18.5

abnormal adrenocortical cell morphology ( J:191801 )

• vacuolated cytoplasm at E18.5

absent adrenal chromaffin cells ( J:191801 )

cellular

abnormal mitochondrial morphology ( J:191801 )

• mitochondria from the zona fasciculate of E17.5 adrenal exhibit few stalks and lack discernable cisternae compared with wild-type mitochondria

nervous system

absent adrenal chromaffin cells ( J:191801 )