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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tab2tm2.1Aki
targeted mutation 2.1, Shizuo Akira
MGI:5464099
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tab2tm2.1Aki/Tab2tm2.1Aki
Tg(Tek-cre)12Flv/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:5464103
cn2
 		Tab2tm2.1Aki/Tab2tm2.1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:5464104
cn3
 		Tab2tm2.1Aki/Tab2tm2.1Aki
Tab3tm1Aki/Tab3tm1Aki
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5502699
cn4
 		Tab2tm2.1Aki/Tab2tm2.1Aki
Tab3tm1Aki/Tab3tm1Aki
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5502700


Genotype
MGI:5464103
cn1
Allelic
Composition		 Tab2tm2.1Aki/Tab2tm2.1Aki
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab2tm2.1Aki mutation (0 available); any Tab2 mutation (31 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal vascular development ( J:191285 )
• as in Map3k7tm1Aki/Map3k7tm1Aki Tnfrsf1atm1Mak/Tnfrsf1atm1Mak Tg(Tek-cre)12Flv mice
• however, endothelial cell proliferation and apoptosis rates are normal
abnormal vitelline vasculature morphology ( J:191285 )
• yolk sacs exhibit lagoon-like and less-branched vessel structures compared with control mice

embryo
abnormal vitelline vasculature morphology ( J:191285 )
• yolk sacs exhibit lagoon-like and less-branched vessel structures compared with control mice




Genotype
MGI:5464104
cn2
Allelic
Composition		 Tab2tm2.1Aki/Tab2tm2.1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab2tm2.1Aki mutation (0 available); any Tab2 mutation (31 available)
Tg(Tek-cre)12Flv mutation (1 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal vascular development ( J:191285 )
• as in Tab2tm2.1Aki/Tab2tm2.1Aki Tg(Tek-cre)12Flv mice




Genotype
MGI:5502699
cn3
Allelic
Composition		 Tab2tm2.1Aki/Tab2tm2.1Aki
Tab3tm1Aki/Tab3tm1Aki
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tab2tm2.1Aki mutation (0 available); any Tab2 mutation (31 available)
Tab3tm1Aki mutation (0 available); any Tab3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:195289 )
• peritoneal B-1a cell numbers are further reduced over reduction seen in Tab2 KO mice
decreased plasma cell number ( J:195289 )
• plasma cell populations are reduced
increased B cell apoptosis ( J:195289 )
• undergo apoptosis more rapidly in response to CpG DNA and anti-IgM but not anti-CD40 stimulation
decreased B cell proliferation ( J:195289 )
• impaired proliferation in response to CpG DNA, anti-IgM, and anti-CD40 stimulation

cellular
increased B cell apoptosis ( J:195289 )
• undergo apoptosis more rapidly in response to CpG DNA and anti-IgM but not anti-CD40 stimulation
decreased B cell proliferation ( J:195289 )
• impaired proliferation in response to CpG DNA, anti-IgM, and anti-CD40 stimulation

hematopoietic system
decreased B-1a cell number ( J:195289 )
• peritoneal B-1a cell numbers are further reduced over reduction seen in Tab2 KO mice
decreased plasma cell number ( J:195289 )
• plasma cell populations are reduced
increased B cell apoptosis ( J:195289 )
• undergo apoptosis more rapidly in response to CpG DNA and anti-IgM but not anti-CD40 stimulation
decreased B cell proliferation ( J:195289 )
• impaired proliferation in response to CpG DNA, anti-IgM, and anti-CD40 stimulation

homeostasis/metabolism




Genotype
MGI:5502700
cn4
Allelic
Composition		 Tab2tm2.1Aki/Tab2tm2.1Aki
Tab3tm1Aki/Tab3tm1Aki
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Tab2tm2.1Aki mutation (0 available); any Tab2 mutation (31 available)
Tab3tm1Aki mutation (0 available); any Tab3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:195289 )
N
• normal production of TNF, IL-6, and other cytokines when stimulated with Pam2CSK4, LPS, or CpG DNA




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory