All Phenotypes Sox2<tm1.2Vlcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox2^tm1.2Vlcg
targeted mutation 1.2, Velocigene
MGI:5464909

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5464913
ht2	Sox2^tm1.2Vlcg/Sox2⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5464912
ht3	Sox2^tm1.1Vep/Sox2^tm1.2Vlcg	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5464914

Allelic Composition	Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1.2Vlcg mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg and Sox2^tm1.1Vep/Sox2^tm1.2Vlcg embryos form disorganized extraembryonic tissues, but fail to form the epiblast, phenocopying Sox2^tm1.1Vep/Sox2^tm1.1Vep embryos

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:191980 )

• shortly after implantation

embryo

absent embryonic epiblast ( J:191980 )

• lack the epithelial cells typical of epiblast

absent egg cylinders ( J:191980 )

increased trophoblast giant cell number ( J:191980 )

Allelic Composition	Sox2^tm1.2Vlcg/Sox2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1.2Vlcg mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg and Sox2^tm1.1Vep/Sox2^tm1.2Vlcg embryos form disorganized extraembryonic tissues, but fail to form the epiblast, phenocopying Sox2^tm1.1Vep/Sox2^tm1.1Vep embryos

normal phenotype

no abnormal phenotype detected ( J:191980 )

• mice exhibit no obvious phenotype

Allelic Composition	Sox2^tm1.1Vep/Sox2^tm1.2Vlcg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)
Sox2^tm1.2Vlcg mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg and Sox2^tm1.1Vep/Sox2^tm1.2Vlcg embryos form disorganized extraembryonic tissues, but fail to form the epiblast, phenocopying Sox2^tm1.1Vep/Sox2^tm1.1Vep embryos

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:191980 )

• shortly after implantation

embryo

absent embryonic epiblast ( J:191980 )

• lack the epithelial cells typical of epiblast

absent egg cylinders ( J:191980 )

increased trophoblast giant cell number ( J:191980 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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