Phenotypes associated with this allele

• Allele Symbol: Trp53^tm3.1Holl
• Allele Name: targeted mutation 3.1, Monica Hollstein
• Allele ID: MGI:5465276
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm3.1Holl/Trp53^tm3.1Holl	Not Specified	MGI:5465277
cx2	Trp53^tm3.1Holl/Trp53^tm3.1Holl Xrcc4^tm1Fwa/Xrcc4^tm1Fwa	involves: 129P2/OlaHsd	MGI:5465278

Genotype
MGI:5465277

hm1

• Allelic Composition: Trp53^tm3.1Holl/Trp53^tm3.1Holl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:191183 )

• in at 3T3 assay, mouse embryonic fibroblasts (MEFs) more readily immortalized compared with Trp53^tm1Holl MEFs

increased thymocyte apoptosis ( J:191183 )

• thymocyte apoptosis is modestly decreased after ionizing radiation treatment compared to in Trp53^tm1Holl thymocytes

hematopoietic system

increased thymocyte apoptosis ( J:191183 )

• thymocyte apoptosis is modestly decreased after ionizing radiation treatment compared to in Trp53^tm1Holl thymocytes

immune system

increased thymocyte apoptosis ( J:191183 )

• thymocyte apoptosis is modestly decreased after ionizing radiation treatment compared to in Trp53^tm1Holl thymocytes

endocrine/exocrine glands

increased thymocyte apoptosis ( J:191183 )

• thymocyte apoptosis is modestly decreased after ionizing radiation treatment compared to in Trp53^tm1Holl thymocytes

Genotype
MGI:5465278

cx2

• Allelic Composition: Trp53^tm3.1Holl/Trp53^tm3.1Holl; Xrcc4^tm1Fwa/Xrcc4^tm1Fwa
• Genetic Background: involves: 129P2/OlaHsd

mortality/aging

embryonic lethality, complete penetrance ( J:191183 )

• no mice are produced