Phenotypes associated with this allele

• Allele Symbol: Srgap3^tm1.1Zi
• Allele Name: targeted mutation 1.1, Dusan Bartsch
• Allele ID: MGI:5465281
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srgap3^tm1.1Zi/Srgap3^tm1.1Zi	B6.129(SJL)-Srgap3^tm1.1Zi	MGI:5465282

Genotype
MGI:5465282

hm1

• Allelic Composition: Srgap3^tm1.1Zi/Srgap3^tm1.1Zi
• Genetic Background: B6.129(SJL)-Srgap3^tm1.1Zi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:192388 )

• some mice from hydrocephalus at a median age of 50 days

behavior/neurological

behavior/neurological phenotype ( J:192388 )

N • mice exhibit normal anxiety-associated behavior, fear conditioning, conditioned taste aversion, spatial memory and short-term and long-term memory

abnormal spatial working memory ( J:192388 )

• mice exhibit decreased spontaneous alteration in a Y-maze compared with wild-type mice

abnormal response to novel object ( J:192388 )

• reduced exploration of objects

abnormal motor capabilities/coordination/movement ( J:192388 )

• mice exhibit increased spontaneous tics compared with wild-type mice

decreased locomotor activity ( J:192388 )

induced hyperactivity ( J:192388 )

♂ • in male, but not female, mice treated with methylphenidate

abnormal social investigation ( J:192388 )

• male and female mice exhibit reduced anogenital exploration compared with wild-type mice

• female mice exhibit increased social evasion compared with wild-type mice

• female mice exhibit reduced nonanogenital exploration and approach and follow behavior compared with wild-type mice

• however, contact behavior is normal

nervous system

cerebral edema ( J:192388 )

• periventricular edema

hydrocephaly ( J:192388 )

enlarged brain ventricles ( J:192388 )

abnormal brain white matter morphology ( J:192388 )

• enlarged white matter tract, most prominent in the corpus callosum with enlargement in the alveus and external capsule

abnormal dendritic spine morphology ( J:192388 )

• longer spines in both basal and apical dendrites

decreased prepulse inhibition ( J:192388 )

♀ • in female mice at high intensity

homeostasis/metabolism

decreased circulating testosterone level ( J:192388 )

♂ • in male mice

cerebral edema ( J:192388 )

• periventricular edema

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:192388