Phenotypes associated with this allele

• Allele Symbol: Tlr4^tm1.1Djh
• Allele Name: targeted mutation 1.1, David J Hackam
• Allele ID: MGI:5465308
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr4^tm1.1Djh/Tlr4^tm1.1Djh	involves: C57BL/6 * FVB/N * SJL	MGI:5520918
hm2	Tlr4^tm1.1Djh/Tlr4^tm1.1Djh	involves: FVB/N	MGI:5465326

Genotype
MGI:5520918

hm1

• Allelic Composition: Tlr4^tm1.1Djh/Tlr4^tm1.1Djh
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

abnormal enterocyte differentiation ( J:193668 )

• increased goblet cell differentiation in cultured enterocytes

homeostasis/metabolism

abnormal bile salt level ( J:193668 )

• reduced in the ileal lumen and stool

decreased susceptibility to injury ( J:193668 )

• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa and minimal cytokine elevation compared with wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

abnormal enterocyte differentiation ( J:193668 )

• increased goblet cell differentiation in cultured enterocytes

Genotype
MGI:5465326

hm2

• Allelic Composition: Tlr4^tm1.1Djh/Tlr4^tm1.1Djh
• Genetic Background: involves: FVB/N

cellular

abnormal enterocyte proliferation ( J:192520 )

• LPS fails to reduce enterocyte proliferation in the colon of newborn mice unlike in wild-type mice

abnormal fibroblast proliferation ( J:192520 )

• mouse embryonic fibroblasts exposed to LPS fail to exhibit a reduction in cell proliferation compared with wild-type cells

immune system

decreased susceptibility to endotoxin shock ( J:192520 )

• mice fail to mount a septic response to the intraperitoneal injection of LPS

• mouse embryonic fibroblasts exposed to LPS fail to exhibit a reduction in cell proliferation compared with wild-type cells

• LPS fails to reduce enterocyte proliferation unlike in wild-type mice

digestive/alimentary system

abnormal enterocyte proliferation ( J:192520 )

• LPS fails to reduce enterocyte proliferation in the colon of newborn mice unlike in wild-type mice