Phenotypes associated with this allele

• Allele Symbol: Esr1^tm4.2Ksk
• Allele Name: targeted mutation 4.2, Kenneth S Korach
• Allele ID: MGI:5465426
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk	involves: C57BL/6 * C57BL/6NTac * CBA	MGI:5465428
cn2	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk Mir22^tm1Boet/Mir22^tm1Boet Tg(Ckmm-cre)5Khn/0	involves: 129S2/SvPas * C57BL/6 * FVB	MGI:6275157
cx3	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk Mir22^tm1Boet/Mir22^tm1Boet	involves: 129S2/SvPas * C57BL/6	MGI:6275156

Genotype
MGI:5465428

hm1

• Allelic Composition: Esr1^tm4.2Ksk/Esr1^tm4.2Ksk
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating testosterone level ( J:191182 )

♀ • serum levels elevated 20X in females

increased circulating luteinizing hormone level ( J:191182 )

♀ • serum levels elevated 6.5X in females

endocrine/exocrine glands

abnormal mammary gland development ( J:191182 )

♀ • impaired mammary gland development in adult females

♀ • ductal rudiment is present

reproductive system

abnormal uterus development ( J:191182 )

♀ • uterine proliferation is impaired

growth/size/body

growth/size/body region phenotype ( J:191182 )

♂N • male growth curves are normal between 50 and 200 days of age

increased body weight ( J:191182 )

♀ • females with greater body weights than controls

increased growth rate ( J:191182 )

♀ • steeper growth curve in females relative to controls

♀ • female growth curve is similar to male growth curve

adipose tissue

increased total body fat amount ( J:191182 )

♀ • females have more body fat than controls

skeleton

increased bone mineral density ( J:191182 )

♀ • mean bone mineral density in females is greater than in controls although bone mineral density is highly variable

integument

abnormal mammary gland development ( J:191182 )

♀ • impaired mammary gland development in adult females

♀ • ductal rudiment is present

Genotype
MGI:6275157

cn2

• Allelic Composition: Esr1^tm4.2Ksk/Esr1^tm4.2Ksk; Mir22^tm1Boet/Mir22^tm1Boet; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

homeostasis/metabolism

increased fatty acid oxidation ( J:266382 )

• mitochondrial in muscle cells

• however, muscle cells exhibit normal total and extramitochondrial fatty acid oxidation

adipose tissue

adipose tissue phenotype ( J:266382 )

N • mice exhibit normal fat amounts unlike mice homozygous for a knock-out allele of Mir22^tm1Boet

growth/size/body

growth/size/body region phenotype ( J:266382 )

N • male and female mice exhibit normal body weight

muscle

muscle phenotype ( J:266382 )

N • mice exhibit normal muscle fiber composition and mitochondrial content

cellular

increased fatty acid oxidation ( J:266382 )

• mitochondrial in muscle cells

• however, muscle cells exhibit normal total and extramitochondrial fatty acid oxidation

Genotype
MGI:6275156

cx3

• Allelic Composition: Esr1^tm4.2Ksk/Esr1^tm4.2Ksk; Mir22^tm1Boet/Mir22^tm1Boet
• Genetic Background: involves: 129S2/SvPas * C57BL/6

growth/size/body

growth/size/body region phenotype ( J:266382 )

N • male and female mice exhibit normal body weight