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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gatmtm1.1Isb
targeted mutation 1.1, Dirk Isbrandt
MGI:5465452
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gatmtm1.1Isb/Gatmtm1.1Isb B6.129-Gatmtm1.1Isb MGI:5465463


Genotype
MGI:5465463
hm1
Allelic
Composition
Gatmtm1.1Isb/Gatmtm1.1Isb
Genetic
Background
B6.129-Gatmtm1.1Isb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatmtm1.1Isb mutation (1 available); any Gatm mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

homeostasis/metabolism
N
• mice exhibit normal feces energy content, glycosuria, metabolic parameters (body temperature and free triiodothyronine or adiponectin serum levels), insulin sensitivity and glucagon levels
• in mice fed a high fat diet
• however, mice supplemented with phosphorylated creatine exhibit normal obesity when fed a high fat diet
• decreased urine levels of creatine, creatinine and guanidine acetate
• in mice fed standard chow
• however, mice supplemented with phosphorylated creatine or fed a high fat diet exhibit normal circulating cholesterol levels
• increased glucose clearance through GLUT4 in skeletal muscle and white adipose tissue
• after pyruvate injection
• after glucose challenge, when fed ad libitum or fed a high fat diet
• however, levels are normal under fasted conditions
• impaired in the liver
• in mice fed standard chow or a high fat diet

growth/size/body
N
• mice supplemented with phosphorylated creatine (Cr) exhibit normal body length, body weight, BMI and body composition
• from 4 weeks onward
• in mice fed a high fat diet
• however, mice supplemented with phosphorylated creatine exhibit normal obesity when fed a high fat diet

adipose tissue
• in mice fed a high fat diet
• in the intestinal, subcutaneous and epigonadal white adipose tissue of mice fed a high fat diet
• in mice fed standard chow or a high fat diet

behavior/neurological
• during the active dark period

liver/biliary system

muscle
• reduced body tension indicating chronic muscular hypotonia

renal/urinary system
• decreased urine levels of creatine, creatinine and guanidine acetate

integument
• in mice fed a high fat diet

endocrine/exocrine glands

skeleton
• severe

cellular





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory