Phenotypes associated with this allele

• Allele Symbol: Usp17lc^tm1Khb
• Allele Name: targeted mutation 1, Kwang-Hyun Baek
• Allele ID: MGI:5466162
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp17lc^tm1Khb/Usp17lc^tm1Khb	either: 129-Usp17lc^tm1Khb or (involves: 129S/SvEv * C57BL/6J)	MGI:5466164
ht2	Usp17lc^tm1Khb/Usp17lc^+	either: 129-Usp17lc^tm1Khb or (involves: 129S/SvEv * C57BL/6J)	MGI:5466165

Genotype
MGI:5466164

hm1

• Allelic Composition: Usp17lc^tm1Khb/Usp17lc^tm1Khb
• Genetic Background: either: 129-Usp17lc^tm1Khb or (involves: 129S/SvEv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:191761 )

• mice are detected until E3.5

embryo

increased embryonic tissue cell apoptosis ( J:191761 )

• in zona pellucida-free embryos

increased trophectoderm apoptosis ( J:191761 )

• TUNEL assays revealed apoptosis of the trophectoderm

failure of blastocyst to hatch from the zona pellucida ( J:191761 )

cellular

increased embryonic tissue cell apoptosis ( J:191761 )

• in zona pellucida-free embryos

increased trophectoderm apoptosis ( J:191761 )

• TUNEL assays revealed apoptosis of the trophectoderm

decreased cell proliferation ( J:191761 )

• in zona pellucida-free embryos

Genotype
MGI:5466165

ht2

• Allelic Composition: Usp17lc^tm1Khb/Usp17lc⁺
• Genetic Background: either: 129-Usp17lc^tm1Khb or (involves: 129S/SvEv * C57BL/6J)

Increased body weight in Usp17lc^tm1Khb/Usp17lc⁺ mice

reproductive system

reproductive system phenotype ( J:191761 )

N • sperm are capable of in vitro fertilization

asthenozoospermia ( J:191761 )

decreased testis weight ( J:191761 )

immune system

increased thymus weight ( J:191761 )

increased B cell number ( J:191761 )

• 4-fold

increased CD4-positive, alpha-beta T cell number ( J:191761 )

• in the thymus

increased CD8-positive, alpha-beta T cell number ( J:191761 )

• in the thymus

decreased regulatory T cell number ( J:191761 )

• 3-fold

growth/size/body

increased body weight ( J:191761 )

endocrine/exocrine glands

increased thymus weight ( J:191761 )

decreased testis weight ( J:191761 )

hematopoietic system

increased thymus weight ( J:191761 )

increased B cell number ( J:191761 )

• 4-fold

increased CD4-positive, alpha-beta T cell number ( J:191761 )

• in the thymus

increased CD8-positive, alpha-beta T cell number ( J:191761 )

• in the thymus

decreased regulatory T cell number ( J:191761 )

• 3-fold

cellular

asthenozoospermia ( J:191761 )