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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr249tm1.1Ebres
targeted mutation 1.1, Emery H Bresnick
MGI:5466176
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr249tm1.1Ebres/Rr249tm1.1Ebres involves: 129 * BALB/cJ * C57BL/6 MGI:5466250
ht2
 		Rr249tm1.1Ebres/Rr249+ involves: 129 * BALB/cJ * C57BL/6 MGI:5466249


Genotype
MGI:5466250
hm1
Allelic
Composition		 Rr249tm1.1Ebres/Rr249tm1.1Ebres
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Hemorrhage in Rr249tm1.1Ebres/Rr249tm1.1Ebres embryos

mortality/aging

hematopoietic system
decreased common myeloid progenitor cell number ( J:191756 )
• from fetal liver hematopoietic precursors
decreased erythroid progenitor cell number ( J:191756 )
• from fetal liver hematopoietic precursors
decreased hematopoietic stem cell number ( J:191756 )
• severe depletion in the fetal liver at E12.5 and E13.5

cardiovascular system
abnormal blood vessel endothelium morphology ( J:191756 )
• discontinuous endothelial cell barrier
hemorrhage ( J:191756 )
• severe at E13.5, including subcutaneous sites in the trunk and the brain
increased vascular permeability ( J:191756 )
• vascular integrity defect

liver/biliary system

homeostasis/metabolism
edema ( J:191756 )
• variable at E13.5




Genotype
MGI:5466249
ht2
Allelic
Composition		 Rr249tm1.1Ebres/Rr249+
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased common myeloid progenitor cell number ( J:191756 )
• from fetal liver hematopoietic precursors
decreased erythroid progenitor cell number ( J:191756 )
• from fetal liver hematopoietic precursors
decreased hematopoietic stem cell number ( J:191756 )
• intermediate depletion in the fetal liver at E12.5 and E13.5
• however, primitive hematopoietic stem/progenitor activity is unaffected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory