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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax4tm1.1Aman
targeted mutation 1.1, Ahmed Mansouri
MGI:5466350
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax4tm1.1Aman/Pax4tm1.1Aman involves: 129S2/SvPas * C57BL/6 * SJL MGI:5466355
cn2
 		Pax4tm1Pgr/Pax4tm1.1Aman
Tg(CMV-cre)1Cgn/0 		involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL MGI:5466356


Genotype
MGI:5466355
hm1
Allelic
Composition		 Pax4tm1.1Aman/Pax4tm1.1Aman
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax4tm1.1Aman mutation (0 available); any Pax4 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192683 )
• normal and fertile




Genotype
MGI:5466356
cn2
Allelic
Composition		 Pax4tm1Pgr/Pax4tm1.1Aman
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax4tm1.1Aman mutation (0 available); any Pax4 mutation (28 available)
Pax4tm1Pgr mutation (0 available); any Pax4 mutation (28 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:192683 )
• some mice die at birth after a cross to transgenic mice expressing CMV-cre
postnatal lethality, incomplete penetrance ( J:192683 )
• some mice die within a few days of birth after a cross to transgenic mice expressing CMV-cre

endocrine/exocrine glands
increased pancreatic alpha cell number ( J:192683 )
• after a cross to transgenic mice expressing CMV-cre
absent pancreatic beta cells ( J:192683 )
• after a cross to transgenic mice expressing CMV-cre
absent pancreatic delta cells ( J:192683 )
• after a cross to transgenic mice expressing CMV-cre




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory